Results 111 to 120 of about 9,019,411 (282)

Cytological Diagnosis of Rare Synchronous Primary Malignancies

Online Journal of Health & Allied Sciences, 2021
Introduction: Synchronous tumours are rare. The defining criteria is the occurrence of more than one tumour simultaneously or within a span of six months, having different histology and involving different organs.
Amita K, Chandana N
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Differences in gene expression between individuals with multiple primary and single primary malignancies

, 2009
Cytogenetic and molecular studies have identified imbalanced chromosomal regions leading to the characterization of several candidate genes. Differences in gene expression were examined in the blood by whole genome microarray analysis among individuals ...
Armakolas, A., Stathopoulos, G. P.
core   +1 more source

Quadruple Primary Malignancies of Liver, Bladder, Lung and Stomach in One Patient

, 2010
Multiple primary malignancies are defined as two or more malignancies in an individual without any relationship between the tumors. Because of advances in the early detection, treatment, and supportive care for cancer, the number of cancer survivors has
Na-Ri Lee, Chang-Yeol Yim, Ho Sung Park, Eun-Kee Song, Hee Sun Kim, Ho-Young Yhim, Jae-Yong Kwak   +6 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Microsatellite instability as biomarker for risk of multiple primary malignancies of the upper aerodigestive tract

, 2001
Head and neck cancer (HNC) patients are at high risk of developing second primary tumors of the upper aerodigestive tract and this is a chief cause of death.
A Franchi, C Bocciolini, I Sardi, L Bruschini, C Mechi, O Gallo, A Frittelli   +6 more
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

From Leukemia to Solid Tumors, Successful Multidisciplinary Management of Three Distinct Primary Cancers in a Single Patient: A Case Report

Clinical Case Reports
A 41‐year‐old man developed three distinct primary malignancies—acute myeloid leukemia, male breast cancer, and metastatic colorectal cancer—within 7 years. This rare case highlights the evolving challenge of multiple primary cancers and demonstrates how
Abolfazl Khalafi‐Nezhad, Nazanin Alemzadeh, Mohammad Hossein Anbardar, Zahra Ghanbarinasab   +3 more
doaj   +1 more source

Generation of the induced pluripotent stem cell line SHUTCMi001-A from a patient with double primary lung and colon cancers

Stem Cell Research
Patients with synchronous multiple primary malignancies often exhibit unique genetic susceptibility. Here, we generated the induced pluripotent stem cell (iPSC) line, SHUTCMi001-A, from a 70-year-old patient with double primary lung squamous cell ...
Jingyi Wei, Guanjin Wu, Chenbing Sun, Lijing Jiao, Ling Xu   +4 more
doaj   +1 more source