Results 51 to 60 of about 9,019,411 (282)

Impact of Synchronous Multiple Primary Malignant Tumors on Newly Diagnosed Hematological Malignancies [PDF]

, 2017
The existence of synchronous multiple primary malignant tumors was not a significant risk factor for patients with newly diagnosed hematological malignancies.
Kotaro Suzuki, Isamu Sugiura, Satoshi Nishiwaki, Shingo Okuno, Okuno, Shingo, Suzuki, Kotaro, Shingo Kurahashi, Kurahashi, Shingo, Sugiura, Isamu, Nishiwaki, Satoshi   +9 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Comparative analysis through propensity score matching in thyroid cancer: unveiling the impact of multiple malignancies

Frontiers in Endocrinology
BackgroundThe incidence of thyroid cancer is on the rise worldwide, with childhood exposure to radiation being the sole acknowledged catalyst for its emergence. Nonetheless, numerous other factors that may pose risks are awaiting thorough examination and
Akram Al-Ibraheem, Akram Al-Ibraheem, Ahmed Saad Abdlkadir, Dhuha Ali Al-Adhami, Egesta Lopci, Amal Al-Omari, Mahmoud Al-Masri, Yacoub Yousef, Nabeela Al-Hajaj, Issa Mohamad, Susanne Singer, Gerasimos P. Sykiotis   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The unfortunate case of triple primary malignancies

, 2022
We herein report a rare case of triple primary malignancies in a single patient. A 51-year-old Burmese lady without a family history of malignancies or known genetic predisposition developed three primary malignancies involving breast, colon and uterus ...
Osman, Mohd Firdauss, Jasmani, Asraf Haslam, Mariapan, Kalyani, Dass, Andre, Lee, Fei Yee   +4 more
core   +1 more source

MULTIPLE PRIMARY MALIGNANCIES: CASE REPORT AND LITERATURE REVIEW

, 2017
Introduction: Among the patients with the diagnosis of cancer, lifetime risk of development of other malignancies is higher than that of the people without cancer diagnosis. In literature, the reports about the patients with multiple primary malignancies
Aydin, Oguz Ugur, Ulas, Arife, Durnali, Ayse GoeK, Tokluoglu, Saadet   +3 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Multiple primary malignancies involving lung: An analysis of 40 cases

, 2008
We aimed to assess the incidence of multiple primary malignancies in primary lung cancer patients. We retrospectively evaluated the clinical files of 1038 primary lung cancer patients diagnosed in 2004.
Yilmaz, Adnan, Sulu, Ebru, Tuncer, Leyla Yagci, Damadoglu, EBRU, Ertugrul, Muyesser   +4 more
core   +1 more source