Results 51 to 60 of about 9,060,069 (257)

Primary Pulmonary Actinomycosis Mimicking Malignancy [PDF]

, 2018
The diagnosis of primary pulmonary actinomycosis (PPA) is still an important challenge in clinical practice due to its clinical and radiographic similarity with other infections and malignant diseases.
Guven, Merve Ilcin, Pınar Mutlu, Nihal Arzu Mirici, Merve İlçin Güven, Mirici, Nihal Arzu, MUTLU, PINAR   +5 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A rare case of urachal carcinoma with multiple lung metastasis that required differentiation from primary lung carcinoma

Respirology Case Reports, 2022
Urachal carcinoma is a rare malignancy of all bladder carcinomas. Metastatic lung tumours showing multiple nodules are rare without a local recurrence.
Kentaro Suzuki, Yoshiro Kai, Masayuki Matsuda, Kazuhide Horimoto, Kazunori Iwai, Masato Takano, Masahito Yoshii, Shigeo Muro   +7 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Implementation of a metastatic malignancy of unknown primary origin service led by a palliative physician [PDF]

, 2018
Background: Cancer of unknown primary is the fourth most common cause of cancer death in the United Kingdom. National guidance in 2010 recommended the establishment of a dedicated unknown primary team to facilitate targeted investigation and symptom ...
Ahmed, W., Clare Farrington, Peter A Bath, Farrington, Clare, Brooks, D., McGregor, M., Bath, Peter, McGregor, Mary, Noble, Bill, Bath, Peter A, Noble, B., Farrington, C., Brooks, David, Ahmed, Wasim, Bath, P.A., Philippa Hughes, Hughes, Philippa, Bill Noble, Hughes, P., David Brooks, Mary McGregor, Wasim Ahmed   +21 more
core   +1 more source

Bone Pathology in Multiple Myeloma: Diagnosis and Treatment

Boğaziçi Tıp Dergisi, 2020
Multiple myeloma is the most common primary bone disease. Incidence has been reported as 3/100.000 in the United States. This neoplasia is characterized by osteolytic bone destruction and monoclonal proliferation of plasma cells.
Erhan Okay, Korhan Özkan
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Oncotype Dx Results in Multiple Primary Breast Cancers

, 2014
Purpose To determine whether multiple primary breast cancers have similar genetic profiles, specifically Oncotype Dx Recurrence Scores, and whether obtaining Oncotype Dx on each primary breast cancer affects chemotherapy recommendations.
Kelley M. Kidwell, Michael J. Toole, Catherine Van Poznak   +2 more
core   +1 more source

Autopsy analysis may contribute to establish actual incidence of second primary malignancies in myeloma

Rare Tumors, 2015
Second primary malignancies (SPMs) are issues for patients with multiple myeloma (MM). There may have been some limitations in prior studies, such as difficulties in a longer follow-up and absence of established screening methods.
Junichiro Takano, Shotaro Hagiwara, Akiyoshi Miwa   +2 more
doaj   +1 more source