Results 71 to 80 of about 9,060,069 (257)

Incidence of malignancy in multiple sclerosis:A cohort study in the Danish Multiple Sclerosis Registry

, 2021
Background: The association between multiple sclerosis and malignancy is controversial and a current appraisal is needed. Objective: To determine the incidence of malignancy in patients with multiple sclerosis compared with the general population and in ...
Veres, Katalin, Foch, Caroline, Nørgaard, Mette, Svingel, Lise S., Sellebjerg, Finn T., Boutmy, Emmanuelle, Sabidó, Meritxell, Magyari, Melinda   +7 more
core   +1 more source

Case Report: A hepatic lesion is not always metastasis: synchronous rectal adenocarcinoma and primary hepatocellular carcinoma followed by a benign necrotic liver nodule

Frontiers in Medicine
BackgroundLiver lesions identified during postoperative surveillance of colorectal cancer are commonly presumed to represent colorectal liver metastases.
Huiying Liu, Jing Gao, Weiting Zhang, Xiaoxia Kou, Huafei Li, Huafei Li, Jinrong Qiu   +6 more
doaj   +1 more source

Triple Metachronous Malignancies with Thyroid Involvement: A Brief Overview of Five Case Reports over 20 Years of Institutional Experience

Diagnostics, 2020
Multiple primary malignant tumors are defined by the development of more than one malignancy in a single patient. These can be subdivided into synchronous or metachronous malignant tumors, depending on their time of appearance, relative to the first ...
Bădan Marius-Ioan, Piciu Doina
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An elderly woman with triple primary metachronous malignancy: A case report and review of literature [PDF]

, 2013
INTRODUCTIONPrevalence of multiple primary malignancies is slowly increasing due to prolonged survival of cancer patients with advances in diagnostic and therapeutic modalities.
Kodlikeri, Pushpa, Advani, Suresh H., Asegaonkar, Balaji N., Sharma, Brijmohan, Asegaonkar, Shilpa, Takalkar, Unmesh   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature

Journal of Medical Case Reports, 2011
Introduction The occurrence of multiple primary cancers is rare. Only a few cases and patient reviews of an association of triple malignancy have been reported.
Ismaili Nabil, Aasab Rachid, Mahfoud Tarik, Boutayeb Saber, Mesmoudi Mohamed, Glaoui Meryem, Errihani Hassan   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Synchronous/Metachronous Prostate Cancer with Other Cancer Sites—The Experience of a Single Center in Romania

Medicina
Background and Objectives: The management of patients with multiple primary malignancies (MPMs) is performed by a multidisciplinary team whose purpose is to individualize the treatment plan and to determine the strategies that will improve the patient’s ...
Gabriela Rahnea-Nita, Mihaela Dumitru, Alexandru Nechifor, Roxana-Andreea Rahnea-Nita, Adrian-Cornel Maier, Liliana Florina Andronache, Andreea Cernea, Alexandru Rebegea, Laura-Florentina Rebegea   +8 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source