Results 91 to 100 of about 9,060,069 (257)

Systems for the management of respiratory disease in primary care - an international series: United Kingdom [PDF]

, 2010
INTRODUCTION: The UK National Health Service (NHS) is essentially publicly funded through general taxation. Challenges facing the NHS include the rise in prevalence of long-term conditions and financial pressures.
Allison Worth, Mark Levy, Worth, Allison, Levy, Mark L., Fletcher, Monica, Pinnock, Hilary, Aziz Sheikh, Monica Fletcher, Hilary Pinnock, Pinnock, Hilary; id_orcid, Hoskins, Gaylor, Levy, Mark, Gaylor Hoskins, Sheikh, Aziz, Levy, Mark L   +14 more
core   +1 more source

Autologous stem cell transplantation for malignancy: a systematic review of the literature

, 2000
A systematic review of the literature was undertaken to assess what published evidence is currently available to support the increasing use of autologous stem cell transplantation (ASCT), and to evaluate the published data with regard to the comparative ...
Simnett, S.J., Stewart, L. A., Johnson, Peter W.M., Morgan, G., Sweetenham, J.   +4 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Recognition of skin malignancy by general practitioners: observational study using data from a population-based randomised controlled trial

, 2009
Skin malignancy is an important cause of mortality in the United Kingdom and is rising in incidence every year. Most skin cancer presents in primary care, and an important determinant of outcome is initial recognition and management of the lesion.
Little, P., George, S., Smith, H., N Jayatilleke, J Primrose (16046528), H Smith (9868238), R Kneebone (16046537), A Lowy, N Jayatilleke (16046531), Leppard, B., S George, Jayatilleke, N., Kneebone, R., A Lowy (12143871), P Pockney, S George (7746566), Pockney, P., J Primrose, R Kneebone, B Leppard, H Smith, B Leppard (16046534), P Pockney (12137145), Primrose, J., P Little, P Little (7705370), Lowy, A.   +26 more
core   +1 more source

Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities

Cancer Cell International
Background The incidence of multiple primary cancers (MPC), especially involving primary lung cancer (PLC) and primary hematologic malignancies (PHM), is rising.
Mengchen Lyu, Lifeng Luo, Ling Zhou, Xiangran Feng, Jin Yang, Ziwei Xu, Xianwen Sun, Zhiyao Bao, Xiaofei Wang, Beili Gao, Yi Xiang   +10 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Public opinion on primary prevention of dementia, multiple sclerosis and Parkinson’s disease [PDF]

This is a policy briefing produced by the NIHR Dementia and Neurodegeneration Policy Research Unit at Queen Mary University of London (DeNPRU-QM). Summary Neurodegenerative diseases such as dementia, multiple sclerosis and Parkinson’s disease are amongst
Marshall, CR, Kenten, C, Carroll on behalf of DeNPRU-QM, C, Browning, S, Pouncey, T, Mukadam, N, Schott, J, Horne, R, Thomson, A, Cooper, C, Carr, G, Rauf, M, Dobson, R, Banerjee, S   +13 more
core   +1 more source

Muir-Torre syndrome - Treatment with isotretinoin and interferon alpha-2a can prevent tumour development [PDF]

, 2000
Muir-Torre syndrome is a genodermatosis in which multiple internal malignancies are associated with cutaneous sebaceous tumours and kerato-acanthomas. A 57-year-old man presented with multiple sebaceous tumours, kerato-acanthomas, verrucous carcinoma of ...
Graefe, Tim, Burgdorf, Walter H. C., Wollina, Uwe, Schulz, Hans-Joachim   +3 more
core   +1 more source

From Leukemia to Solid Tumors, Successful Multidisciplinary Management of Three Distinct Primary Cancers in a Single Patient: A Case Report

Clinical Case Reports
A 41‐year‐old man developed three distinct primary malignancies—acute myeloid leukemia, male breast cancer, and metastatic colorectal cancer—within 7 years. This rare case highlights the evolving challenge of multiple primary cancers and demonstrates how
Abolfazl Khalafi‐Nezhad, Nazanin Alemzadeh, Mohammad Hossein Anbardar, Zahra Ghanbarinasab   +3 more
doaj   +1 more source