Results 41 to 50 of about 940,352 (300)

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Synchronous Triple Primary Gastrointestinal Tract Malignancies: A Case Report [PDF]

The Korean Journal of Helicobacter and Upper Gastrointestinal Research
Multiple primary malignant neoplasms are defined as the occurrence of two or more distinct malignant neoplasms in a single patient. However, synchronous triple primary malignant neoplasms have rarely been reported.
Hyeon Min Rim, Young Min Rah, Ju Seok Kim   +2 more
doaj   +1 more source

Cutaneous Involvement in Diseases with Plasma Cell Differentiation: Diagnostic Approach

Current Oncology, 2022
Neoplasms with plasma cell differentiation may occasionally involve the skin. Cutaneous lesions may represent the first sign of an underlying systemic plasma cell malignancy, such as multiple myeloma, or the skin itself may be the primary site of ...
Magda Zanelli, Andrea Palicelli, Francesca Sanguedolce, Maurizio Zizzo, Alessandra Filosa, Linda Ricci, Camilla Cresta, Giovanni Martino, Alessandra Bisagni, Eleonora Zanetti, Francesco di Donato, Beatrice Melli, Alessandra Soriano, Luca Cimino, Alberto Cavazza, Lisa Francesca Vivian, Stefano Ascani   +16 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Multiple primary malignant neoplasms associated with genitourinary cancer [PDF]

, 1996
当院泌尿器科で発見された尿路性器癌392例の中, 重複癌(三重癌も含む)と診断された42例について臨床的検討を行った. 1)発生頻度は重複癌9.9%, 三重癌0.7%であった.男女比は5:1であった. 2)尿路性器系重複癌の臓器別発生頻度は単発癌のそれとほぼ同じであったが, 前立腺癌にやや多い傾向がみられた. 3)他臓器系の癌の組み合わせでは, 胃癌, 膵癌など消化器系の癌の比率が高い傾向がみられた.
深貝, 隆志, 石原, 理裕, 丸山, 邦夫, 内藤, 善文, 船橋, 健二郎   +4 more
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Impact of Diabetes Mellitus on the Second Primary Malignancies in Colorectal Cancer Patients

Frontiers in Oncology, 2021
IntroductionAll colorectal cancer (CRC) survivors have an increased risk of developing second primary malignancies (SPMs). The association between diabetes mellitus (DM) and the risk of cancer is well known. However, the role of DM and its therapy in the
Jana Halamkova, Jana Halamkova, Jana Halamkova, Tomas Kazda, Tomas Kazda, Lucie Pehalova, Lucie Pehalova, Roman Gonec, Sarka Kozakova, Lucia Bohovicova, Ondrej Slaby, Ondrej Slaby, Ondrej Slaby, Regina Demlova, Regina Demlova, Marek Svoboda, Marek Svoboda, Igor Kiss, Igor Kiss   +18 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Current knowledge and future research directions in treatment-related second primary malignancies

EJC Supplements, 2014
Currently, 17–19% of all new primary malignancies occur in survivors of cancer, causing substantial morbidity and mortality. Research has shown that cancer treatments are important contributors to second malignant neoplasm (SMN) risk.
Lindsay M. Morton, Anthony J. Swerdlow, Michael Schaapveld, Safaa Ramadan, David C. Hodgson, John Radford, Flora E. van Leeuwen   +6 more
doaj   +1 more source