Results 81 to 90 of about 212,635 (266)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

On multiple roots in Descartes’ Rule and their distance to roots of higher derivatives

open access: yesJournal of Computational and Applied Mathematics, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Parallel square-root iterations for multiple roots

open access: yesComputers & Mathematics with Applications, 1980
AbstractIn [1] Laguerre's method has been extended to determine all simple roots of a polynomial together with error bounds at each iteration step. In this paper we extend the previous algorithm to multiple complex roots and show that, also in this case, the convergence rate is of order four. Some numerical examples illustrate the theoretical results.
openaire   +2 more sources

Method for finding multiple roots of polynomials

open access: yesComputers & Mathematics with Applications, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chang-Dau Yan, Wei-Hua Chieng
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

New Families of Third-Order Iterative Methods for Finding Multiple Roots

open access: yesJournal of Applied Mathematics, 2014
Two families of third-order iterative methods for finding multiple roots of nonlinear equations are developed in this paper. Mild conditions are given to assure the cubic convergence of two iteration schemes (I) and (II).
R. F. Lin   +5 more
doaj   +1 more source

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