Results 91 to 100 of about 20,743,393 (306)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Construct validity, dimensionality and factorial invariance of the Rosenberg Self Esteem Scale: A bifactor modelling approach among children of prisoners [PDF]
, 2014 The Rosenberg Self Esteem Scale (RSES; Rosenberg, 1989) has traditionally been conceptualised as a unidimensional measure of self-esteem but empirical evidence is equivocal, with some studies supporting a one-factor solution and others favouring ...
Daniel Boduszek +7 more
core +1 more source
On the use of the multiple scale method in solving ‘difficult’ bifurcation problems [PDF]
Mathematics and Mechanics of Solids, 2015 Several algorithms consisting in ‘non-standard’ versions of the Multiple Scale Method are illustrated for ‘difficult’ bifurcation problems. Preliminary, the ‘easy’ case of bifurcation from a cluster of distinct eigenvalues is addressed, which requires using integer power expansions, and it leads to bifurcation equations all of the same order.
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Scientific ReportsIncreasing the span length of stay cables markedly increases their susceptibility to parametric resonance. This study investigates mitigating parametric resonance in stay cables using a parallel inerter damper and focuses on a methodology to obtain the ...
Zengwei Guo +3 more
doaj +1 more source
The Scientific World Journal, 2015 Multiscale nondestructive characterization of coal microscopic physical structure can provide important information for coal conversion and coal-bed methane extraction.
Haipeng Wang +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source