Results 81 to 90 of about 15,981,515 (305)

An Extended Method of Multiple Scales

Abstract Perturbation techniques have long proven useful for analytically describing the dynamics of weakly nonlinear systems. The Method of Multiple Scales (MMS) is one such technique, popular for its versatility and structured approach to handling systems with multiple underlying time scales.
Nidish Narayanaa Balaji, Max J. Miller III, D. Dane Quinn   +2 more
openaire   +1 more source

Multiple-Scales Method and Numerical Simulation of Singularly Perturbed Boundary Layer Problems [PDF]

, 2016
In this paper, Multiple-scales method is presented for solving second and third order singularly perturbed problems with the boundary layer at one end either left or right.
Gupta, Parul, Kumar, Manoj
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

NONLINEAR PRIMARY RESONANCE OF A CIRCULAR SANDWICH PLATE UNDER STATIC LOAD

Jixie qiangdu, 2021
Based on Reissner’s sandwich plate theory,the nonlinear dynamic equations of the circular sandwich plate under static load are established by using the Hamilton principle.
GUO Wei, DU GuoJun, HU YuDa
doaj  

On the use of the multiple scale method in solving ‘difficult’ bifurcation problems [PDF]

Mathematics and Mechanics of Solids, 2015
Several algorithms consisting in ‘non-standard’ versions of the Multiple Scale Method are illustrated for ‘difficult’ bifurcation problems. Preliminary, the ‘easy’ case of bifurcation from a cluster of distinct eigenvalues is addressed, which requires using integer power expansions, and it leads to bifurcation equations all of the same order.
openaire   +2 more sources

On the multiple scales perturbation method for difference equations [PDF]

, 2007
In the classical multiple scales perturbation method for ordinary difference equations (O Delta Es) as developed in 1977 by Hoppensteadt and Miranker, difference equations (describing the slow dynamics of the problem) are replaced at a certain moment in ...
Van Horssen, W.T., M. C. ter Brake, Ter Brake, M.C., Ter Brake, M.C. (author), W. T. van Horssen, Van Horssen, W.T. (author)   +5 more
core   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Detecting separate time scales in genetic expression data

BMC Genomics, 2010
Background Biological processes occur on a vast range of time scales, and many of them occur concurrently. As a result, system-wide measurements of gene expression have the potential to capture many of these processes simultaneously.
Fink Thomas MA, Brady Siobhan M, Orlando David A, Benfey Philip N, Ahnert Sebastian E   +4 more
doaj   +1 more source