Results 51 to 60 of about 4,721,122 (242)

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Association of Relapse of Multiple Sclerosis with Increased Serum Levels of Leptin and Decreased Aerobic Capacity in Women

مجله دانشکده پزشکی اصفهان, 2017
Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease, with an unclear mechanism, and characterized by axonal damage, demyelination and increase inflammatory. Recently, it has been found that leptin plays a role in the pathogenesis of
Motahareh Mokhtarzadeh, Nastaran Majdinasab, Raoof Negaresh, Rohollah Ranjbar   +3 more
doaj  

SWiss Atorvastatin and Interferon Beta-1b Trial In Multiple Sclerosis (SWABIMS) - rationale, design and methodology

Trials, 2009
Background Statins have anti-inflammatory and immunomodulatory properties in addition to their lipid-lowering effects. Currently, the effects of statins on multiple sclerosis are still controversial.
Mattle Heinrich P, Kamm Christian P
doaj   +1 more source

Fluoxetine as disease modifying treatment in multiple sclerosis : rationale, evaluation of the use of MRI to monitor treatment, and preliminary findings [PDF]

, 2009
Patients with multiple sclerosis (MS) lack astrocytic β2-adrenergic receptors and this may contribute to the focal inflammatory demyelinating lesions and axonal degeneration that characterize this disease.
Mostert, Jop Pieter,, Mostert, Jop Pieter   +1 more
core   +16 more sources

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

Comparison some of the syntactic skills in Relapsing Remitting Multiple sclerosis and normal adults resident in Esfahan Province

مجله پژوهش در علوم توانبخشی, 2013
Introduction: Multiple sclerosis is a progressive disease of the central nervous system that deteriorates myelin sheath and produce plaques in white matters of the brain and spinal cord.
Sedigheh Jamalpour, Nahid Baharlooie, Fereshteh Ashtari, Fereshteh Shamsian, Morteza Sedehi   +4 more
doaj   +1 more source

Neural correlates of alerting and orienting impairment in multiple sclerosis patients. [PDF]

PLoS ONE, 2014
BackgroundA considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied.
Manuel Vázquez-Marrufo, Alejandro Galvao-Carmona, Javier J González-Rosa, Antonio R Hidalgo-Muñoz, Mónica Borges, Juan Luis Ruiz-Peña, Guillermo Izquierdo   +6 more
doaj   +1 more source

Experiences of Relapsing Remitting Multiple Sclerosis and Disease Modifying Treatment: A phenomenological inquiry [PDF]

A review of the body of knowledge has provided an insightful overview of the significant strides taken in the field of multiple sclerosis. For instance, the literature has made clear the considerable impact this autoimmune disease can have on an ...
Patel, Dipesh
core   +1 more source

Cerebrospinal fluid ATP metabolites in multiple sclerosis [PDF]

, 2010
Increased axonal energy demand and mitochondrial failure have been suggested as possible causes for axonal degeneration and disability in multiple sclerosis.Our objective was to test whether ATP depletion precedes clinical, imaging and biomarker evidence
Uitdehaag, BMJ, Di Pietro, V., Barkhof, F., Killestein, J, Belli, A.; id_orcid, Killestein, J., Uitdehaag, B.M.J., Eikelenboom, M.J., University of Catania, Tavazzi, B, Petzold, A.F.S., Petzold, A., Petzold, A, Belli, A., Eikelenboom, MJ, Lazzarino, G., Lazzarino, G, Di Pietro, V, Polman, CH, Amorini, A.M., Barkhof, F, Tavazzi, B., Polman, C.H., Belli, A, Di Pietro, V.; id_orcid, Amorini, AM, Pietro, V. Di   +26 more
core   +1 more source