Results 111 to 120 of about 6,039,132 (349)
Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis
Annals of Neurology, 2017 Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations.
G. Disanto +33 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich +10 more
wiley +1 more source
GSC Biological and Pharmaceutical SciencesMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to diffuse neurodegeneration in the entire brain. In this review, the spectrum of MS lesion s and their relation to the inflammatory process is described. Pathology suggests that
Garlapati. Usha Kiran +4 more
openaire +3 more sources
MULTIPLE SCLEROSIS: THE LOCATION OF LESIONS WITH RESPECT TO SYMPTOMS [PDF]
, 1922 E. W. Taylor
openalex +1 more source
Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam +6 more
wiley +1 more source
Biochemical Studies on Sera or Cerebrospinal Fluids of Neurologically Normal Persons and Patients with Multiple Sclerosis [PDF]
, 1959 Ervin Kovács, J. Kovács
openalex +3 more sources
Nature CommunicationsMucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin metabolites presented on the non-polymorphic MHC class I-related protein 1 (MR1 ...
Mark Walkenhorst +14 more
doaj +1 more source