Results 91 to 100 of about 6,788,532 (255)

A taxonomy of cognitive phenotypes in Multiple Sclerosis: a 1-year longitudinal study

Scientific Reports
As meaningful measure of cognitive impairment (CI), cognitive phenotypes provide an avenue for symptom management and individualized rehabilitation. Since CI is highly variable in severity and progression, monitoring cognitive phenotypes over time may be
Jessica Podda, Federica Di Antonio, Andrea Tacchino, Ludovico Pedullà, Erica Grange, Mario Alberto Battaglia, Giampaolo Brichetto, Michela Ponzio   +7 more
doaj   +1 more source

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations [PDF]

, 2017
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesA meta-analysis of publicly available summary statistics on multiple sclerosis ...
Aarsland, Dag,, Alfredsson, Lars,, Andreassen, Ole A.,, Benediktsson, Rafn,, Bjarnason, Ragnar,, Bjornsdottir, Unnur S.,, Bjornsson, Einar S.,, Bjornsson, Sigurdur,, Bos, Steffan Daniël,, Celius, Elisabeth G.,, Djurovic, Srdjan,, Euesden, Jack,, Fladby, Tormod,, Geirsson, Arni J.,, Gislason, Thorarinn,, Grondal, Gerdur,, Gudbjartsson, Daniel F.,, Gustafsson, Omar,, Harbo, Hanne F.,, Hillert, Jan,, Hjaltason, Haukur,, Ingason, Andres,, Johannesson, Ari,, Jonasson, Jon G.,, Jonsdottir, Ingileif,, Jonsson, Stefan,, Knudsen, Gun Peggy,, Kockum, Ingrid Skelton,, Kristjansdottir, Helga,, Kristjansdottir, Sjofn, Ludviksson, Bjorn Runar,, Lund University., Masson, Gisli,, Mikaelsdottir, Evgenia,, Myhr, Kjell Morten,, Nilsson, Bjorn,, Olafsson, Elias,, Olafsson, Jon Hjaltalin,, Olafsson, Sigurgeir,, Olsson, Tomas,, Orvar, Kjartan B., Rafnar, Thorunn,, Sigurdsson, Snaevar,, Sigurgeirsson, Bardur,, Stefansson, Hreinn,, Stefansson, Kari,, Steinsson, Kristjan,, Stridh, Pernilla,, Sulem, Patrick,, Thorleifsson, Gudmar,, Thorsson, Arni V.,, Thorsteinsdottir, Unnur,, Valdimarsson, Helgi,, Valdimarsson, Trausti   +53 more
core   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. [PDF]

, 2016
ObjectiveWe sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality.MethodsWe conducted mendelian randomization (MR ...
Alfredsson, Lars, Barcellos, Lisa F, Bäärnhielm, Maria, Gianfrancesco, Milena, Glymour, M Maria, Gyllenberg, Alexandra, Hedström, Anna Karin, Hillert, Jan, Kockum, Ingrid, Link, Jenny, Mok, Amanda, Olsson, Tomas, Quach, Hong, Rhead, Brooke, Schaefer, Catherine, Shao, Xiaorong, Shen, Ling   +16 more
core   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Lancet Neurology, 2019
Summary Background Multiple sclerosis is the most common inflammatory neurological disease in young adults. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic method of quantifying various effects of a given ...
Mitchell T William J Emma Zulfiqar A Tsegaye Tewelde Simon Wallin Culpepper Nichols Bhutta Gebrehiwot Hay Kha, M. Wallin, W. Culpepper, Emma Nichols, Z. Bhutta, T. Gebrehiwot, Simon Iain Hay, I. Khalil, Kristopher J. Krohn, Xiaofeng Liang, M. Naghavi, A. Mokdad, M. Nixon, R. Reiner, B. Sartorius, Mari Smith, R. Topor-Madry, A. Werdecker, T. Vos, V. Feigin, C. Murray   +20 more
semanticscholar   +1 more source

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Multiple sclerosis susceptibility alleles in African Americans. [PDF]

, 2010
Multiple sclerosis (MS) is an autoimmune demyelinating disease characterized by complex genetics and multifaceted gene-environment interactions. Compared to whites, African Americans have a lower risk for developing MS, but African Americans with MS have
Caillier, SJ, Cree, BCA, Cross, AH, De Jager, PL, Gourraud, P-AF, Hauser, SL, Herbert, J, Johnson, BA, Khan, OA, Oksenberg, JR, Taylor, EM, Wang, J   +11 more
core  

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
The authors acknowledge the support of the Barts and the London Charity, the Multiple Sclerosis Society of Great Britain and Northern Ireland, the National Multiple Sclerosis Society, USA, notably the National Centre for the Replacement, Refinement ...
A Compston, AJ Coles, BB Thomas, C Bjartmar, CKS Leung, D Baker, DA Bechtold, David Baker, DB Fernandes, DW Hampton, E Bettelli, E Bettelli, F Hafezi, G Feng, G Pryce, Gavin Giovannoni, J Goverman, J Oh, JA Black, JA Cohen, JK O’Neill, JM Coquet, K Raju, Katie Lidster, KM Galetta, L Steinman, LS Talman, LS Talman, M Kleinewietfeld, Mark D. Baker, MM Morris-Downes, Pablo Villoslada, Pete Coffey, Peter Munro, R Dutta, R Kapoor, S Al-Izki, S Al-Izki, S Al-Izki, S Gnanapavan, S Mader, Samuel J. Jackson, SG Waxman, SJ Piddlesden, T Hayton, T Svingen, X Wang, Y Guan, Z Ahmed, Zubair Ahmed   +49 more
core   +4 more sources