Results 71 to 80 of about 458,215 (302)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A taxonomy of cognitive phenotypes in Multiple Sclerosis: a 1-year longitudinal study

Scientific Reports
As meaningful measure of cognitive impairment (CI), cognitive phenotypes provide an avenue for symptom management and individualized rehabilitation. Since CI is highly variable in severity and progression, monitoring cognitive phenotypes over time may be
Jessica Podda, Federica Di Antonio, Andrea Tacchino, Ludovico Pedullà, Erica Grange, Mario Alberto Battaglia, Giampaolo Brichetto, Michela Ponzio   +7 more
doaj   +1 more source

Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency

Scientific Reports, 2021
The improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the last years of life.
Ainhoa Alberro, Andrea Iribarren-Lopez, Matías Sáenz-Cuesta, Ander Matheu, Itziar Vergara, David Otaegui   +5 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

T2 lesion location really matters: a 10 year follow-up study in primary progressive multiple sclerosis

, 2010
Objectives: Prediction of long term clinical outcome in patients with primary progressive multiple sclerosis (PPMS) using imaging has important clinical implications, but remains challenging.
Polman, C., Barkhof, F., Montalban, X, CHARD D, Thompson, A, Polman, C, F. Barkhof, Chard, D, Samson, R., D. Miller, Bodini, B., A. Thompson, Samson, R, MONTALBAN X, R. Samson, Rovira, A, POLMAN C, KHALEELI Z, O. Ciccarelli, Filippi, M., N. De Stefano, Barkhof, F, BATTAGLINI, MARCO, B. Bodini, A. Rovira, Battaglini, M, Polman, C.H., Chard, D., CICCARELLI O., Miller, D., Rovaris, M, Battaglini, M., Thompson, A., De Stefano, N., X. Montalban, MILLER D, ROVARIS M, FILIPPI M, D. Chard, Khaleeli, Z, SAMSON R, ROVIRA A, THOMPSON A, Rovaris, M., De Stefano, N, Rovira, A., Z. Khaleeli, Bodini, B, BODINI B, M. Filippi, Miller, D, BARKHOF F, DE STEFANO, NICOLA, M. Rovaris, Montalban, X., Ciccarelli, O., Ciccarelli, O, Khaleeli, Z., M. Battaglini, C. Polman, Filippi, M   +60 more
core   +1 more source

Skin warts during fingolimod treatment in patients with multiple sclerosis [PDF]

, 2019
Background: Fingolimod is associated with different infections including lower respiratory tract, herpes virus, cryptococcal meningitis, histoplasmosis, progressive multifocal leukoencephalopathy, atypical mycobacterial infections, kaposi sarcoma and ...
Massouh, Joelle, Jaafar, Nesreen, Yamout, Bassem I., Zeineddine, Maya M.   +3 more
core   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

The Bayesian risk estimate at onset (BREMSO) correlates with cognitive and physical disability in patients with early multiple sclerosis [PDF]

, 2018
Background: Prevention of long-term disability is the goal of therapeutic intervention in Relapsing Remitting MS (RRMS). The Bayesian Risk Estimate for MS at Onset (BREMSO) gives an individual risk score predicting disease evolution into Secondary ...
Jalkh, Youmna, Hannoun, S., Haddad, Ribal, Saba, Leslie, Khoury, Samia J., El-Ayoubi, Nabil K., Yamout, Bassem I., Said, Marianne   +7 more
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination

, 2023
Background:People with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs) have attenuated IgG response following COVID-19 vaccination; however, the clinical consequences remain unclear.Objective:To report COVID-19 rates in ...
Hibbert, A, Katharine E Harding, Samantha Loveless, Tank, Pooja, Matthew Upcott, Upcott, M, Schmierer, K, Robertson, NP, Richards, A, Dobson, R, Richards, Aidan, Zaloum, Safiya, Valerie Anderson, David Baker, Vickaryous, N, Baker, David, Wood, Callum, Tallantyre, Emma, Anderson, Valerie, Pooja Tank, Dobson, Ruth, Zaloum, Safiya A, Loveless, Samantha, Schmierer, Klaus, Callum H Wood, Harding, Katherine, Zaloum, SA, Katila George, Aimee Hibbert, Ruth Dobson, Kang, Angray S, George, Katila, Hibbert, Aimee, Moat, Stuart J., Stephen Jolles, Angray S Kang, Emma C Tallantyre, Robertson, Neil P., Baker, D, Jolles, Stephen, Ingram, Gillian, Willis, Mark, Stuart J Moat, Harding, Katharine E, Willis, M, Kang, Angray, Gillian Ingram, Harding, KE, Tallantyre, Emma C, Tank, P, Mark Willis, Gavin Giovannoni, Moat, Stuart J, Moat, SJ, Rios, F, Rios, Francesca, Ingram, G, Randy, Chance, Evangelou, Nikos, Chance, Randy, Neil P Robertson, Nicola Vickaryous, Tallantyre, EC, Robertson, Neil P, Safiya A Zaloum, Wood, Callum H, Randy Chance, Upcott, Matthew, Aidan Richards, Anderson, V, Klaus Schmierer, Loveless, S, Giovannoni, Gavin, Evangelou, N, Jolles, S, Vickaryous, Nicola, Nikos Evangelou, Chance, R, Kang, AS, Giovannoni, G, Francesca Rios, Wood, CH, George, K   +82 more
core   +1 more source