Results 61 to 70 of about 458,215 (302)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Patterns of care for Multiple Sclerosis in a setting of universal care access: A cross-sectional study

, 2019
BACKGROUND Current guidelines recommend regular neurological MS care in persons diagnosed with MS, but little is known about implementation of this recommendation or potential access barriers.
Rodgers, S., Kaufmann, Marco; https://orcid.org/, Kuhle, J., Puhan, M.A., Puhan, Milo A, Kuhle, Jens, Puhan, M. A., Kamm, Christian P, Kesselring, Jürg, Rodgers, Stephanie, Pot, Caroline, von Wyl, Viktor, Czaplinski, Adam, Barin, L., Kamm, C.P., von Wyl, V., Barin, Laura, Salmen, A., Ajdacic-Gross, Vladeta, Pot, C., Salmen, Anke, Kaufmann, M., Chan, A., Czaplinski, A., Kamm, Christian P., Swiss Multiple Sclerosis Registry, Chan, Andrew, Gobbi, C., Ajdacic-Gross, V., Gobbi, Claudio, Kesselring, J.   +30 more
core   +1 more source

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P, Baker, MD, Coffey Pete, Jackson, SJ, Gavin Giovannoni, Baker David, Samuel J. Jackson (468645), Zubair Ahmed (9352), Jackson Samuel J., Zubair Ahmed, Ahmed, Z, Mark D Baker, Pete Coffey (422262), David Baker, Samuel J Jackson, Gavin Giovannoni (125820), Giovannoni Gavin, Munro Peter, Ahmed Zubair, Pete Coffey, David Baker (11642), Peter Munro (479715), Peter Munro, Lidster Katie, Baker Mark D., Baker, D, Lidster, K, Mark D. Baker (146531), Katie Lidster, Munro, P, Katie Lidster (479714), Giovannoni, G   +31 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Socioeconomic status of the elderly MS population compared to the general population: a nationwide Danish matched cross-sectional study

Frontiers in Neurology, 2023
Introduction/objectivesMultiple sclerosis (MS) leads to physical and cognitive disability, which in turn impacts the socioeconomic status of the individual.
Malthe Faurschou Wandall-Holm, Rolf Pringler Holm, Luigi Pontieri, Finn Sellebjerg, Melinda Magyari, Melinda Magyari   +5 more
doaj   +1 more source

Review: ‘Gimme five’: future challenges in multiple sclerosis. ECTRIMS Lecture 2009 [PDF]

, 2010
This article is based on the ECTRIMS lecture given at the 25th ECTRIMS meeting which was held in Düsseldorf, Germany, from 9 to 12 September 2009. Five challenges have been identified: (1) safeguarding the principles of medical ethics; (2) optimizing the
Hohlfeld, Reinhard, Hohlfeld, R., Reinhard Hohlfeld   +2 more
core   +1 more source

Multiple Sclerosis Therapy Consensus Group (MSTCG): position statement on disease-modifying therapies for multiple sclerosis (white paper).

, 2021
Multiple sclerosis is a complex, autoimmune-mediated disease of the central nervous system characterized by inflammatory demyelination and axonal/neuronal damage.
Hartung, H.P., Bittner, S., Guger, M., Lünemann, J.D., Berghoff, M., Tumani, H., Deisenhammer, F., Heidenreich, F., Meyding-Lamadé, U., Wiendl, H., Gehring, K., Gass, A., Schmidt, S., Enzinger, C., Weber, F., Haghikia, A., Berger, T., Linker, R., Mäurer, M., Leussink, V.I., Platten, M., Leutmezer, F., Zipp, F., Ziemssen, T., Lutterotti, A., Di Pauli, F., Fertl, E., Derfuss, T., Baum, K., Kallmann, B., Chan, A., Weber, M.S., Czaplinski, A., Aktas, O., Kleinschnitz, C., Hoffmann, O., Gobbi, C., Limmroth, V., Klotz, L., Gold, R., Rieckmann, P., Goebels, N., Zettl, U.K., Meuth, S.G., Du Pasquier, R.   +44 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Efficacy of intrathecal mesenchymal stem cell-neural progenitor therapy in progressive MS: results from a phase II, randomized, placebo-controlled clinical trial

Stem Cell Research & Therapy
Background Mesenchymal stem cell-neural progenitors (MSC-NPs) are a bone marrow mesenchymal stem cell (MSC)-derived ex vivo manipulated cell product with therapeutic potential in multiple sclerosis (MS).
Violaine K. Harris, James Stark, Armistead Williams, Morgan Roche, Michaela Malin, Anjali Kumar, Alyssa L. Carlson, Cara Kizilbash, Jaina Wollowitz, Caroline Andy, Linda M. Gerber, Saud A. Sadiq   +11 more
doaj   +1 more source

A meta-analysis of genomic screens in multiple sclerosis

, 2001
We combined the raw genotyping data from three large multiple sclerosis genome screens and performed a global meta-analysis in order to compare and summarize the linkage results from the different studies. In alphabetical order, the screens provided data
Cooperative, The Transatlantic Multiple Sclerosis Genetics
core   +1 more source