Results 61 to 70 of about 6,788,532 (255)

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis. [PDF]

, 2019
Chronic active and slowly expanding lesions with smouldering inflammation are neuropathological correlates of progressive multiple sclerosis pathology.
Arnold, Douglas L, Barkhof, Frederik, Belachew, Shibeshih, Bernasconi, Corrado, Elliott, Colm, Fecker, Julian, Hauser, Stephen L, Kappos, Ludwig, Model, Fabian, Wei, Wei, Wolinsky, Jerry S   +10 more
core   +1 more source

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Science, 2019
Genetic roots of multiple sclerosis The genetics underlying who develops multiple sclerosis (MS) have been difficult to work out. Examining more than 47,000 cases and 68,000 controls with multiple genome-wide association studies, the International ...
N. A. Patsopoulos, N. A. Patsopoulos, S. Baranzini, A. Santaniello, P. Shoostari, C. Cotsapas, G. Wong, Ashley H Beecham, T. James, J. Replogle, I. Vlachos, C. McCabe, T. Pers, T. Pers, A. Brandes, C. White, B. Keenan, M. Cimpean, P. Winn, Ioannis-Pavlos Panteliadis, A. Robbins, Till F. M. Andlauer, O. Zarzycki, B. Dubois, A. Goris, H. Søndergaard, F. Sellebjerg, P. Sørensen, H. Ullum, L. Thørner, J. Saarela, I. Cournu-Rebeix, V. Damotte, B. Fontaine, L. Guillot-Noel, M. Lathrop, S. Vukusic, A. Berthele, Viola Pongratz, C. Gasperi, C. Graetz, V. Grummel, B. Hemmer, Muni Hoshi, B. Knier, T. Korn, C. Lill, F. Luessi, M. Muehlau, F. Zipp, E. Dardiotis, C. Agliardi, A. Amoroso, N. Barizzone, M. Benedetti, L. Bernardinelli, P. Cavalla, F. Clarelli, G. Comi, D. Cusi, F. Esposito, L. Ferré, D. Galimberti, C. Guaschino, M. Leone, V. Martinelli, L. Moiola, M. Salvetti, M. Sorosina, D. Vecchio, A. Zauli, S. Santoro, N. Mancini, M. Zuccalà, J. Mescheriakova, C. Duijn, S. Bos, E. Celius, A. Spurkland, M. Comabella, X. Montalban, L. Alfredsson, I. Bomfim, D. Gómez-Cabrero, J. Hillert, M. Jagodic, M. Lindén, F. Piehl, I. Jelcic, Roland Martin, M. Sospedra, A. Baker, M. Ban, C. Hawkins, P. Hysi, S. Kalra, F. Karpe, J. Khadake, G. Lachance, P. Molyneux, M. Neville, J. Thorpe, E. Bradshaw, S. Caillier, P. Calabresi, B. Cree, A. Cross, Mary F. Davis, P. D. Bakker, S. Delgado, M. Dembele, K. Edwards, K. Fitzgerald, I. Frohlich, P. Gourraud, J. Haines, H. Hakonarson, D. Kimbrough, N. Isobe, I. Konidari, E. Lathi, Michelle H. Lee, Tai-an Li, D. An, A. Zimmer, L. Madireddy, C. Manrique, M. Mitrovič, M. Olah, E. Patrick, M. Pericak-Vance, L. Piccio, C. Schaefer, H. Weiner, K. Lage, R. Scott, J. Lechner-Scott, R. Leal, P. Moscato, D. Booth, G. Stewart, S. Vucic, Grant Pame, Michael BamettO, D. Mason, L. Griffiths, S. Broadley, L. Tajouri, A. Baxter, M. Slee, B. Taylor, J. Charlesworth, T. Kilpatrick, J. Rubio, V. Jokubaitis, J. Wiley, H. Butzkueven, S. Leslie, A. Motyer, J. Stankovich, W. Carroll, A. Kermode, Marzena Edrin, M. Barclay, L. Peyrin-Biroulet, M. Chamaillard, J. Colombe, M. Cottone, A. Croft, R. D'Incà, J. Halfvarson, K. Hanigan, P. Henderson, J. Hugot, A. Karban, N. Kennedy, M. Khan, M. Lémann, A. Levine, D. Massey, M. Milla, Grant W. Motoey, S. M. Ng, Joannis Oikonomnou, H. Peeters, D. Proctor, J. Rahier, R. Roberts, P. Rutgeerts, F. Seibold, L. Stronati, K. Taylor, L. Törkvist, Kullak Ublick, J. V. Limbergen, A. Gossum, M. Vatn, Hu Zhang, Wei Zhang, P. Donnelly, I. Barroso, Jenefer M. Blackwe, E. Bramon, M. Brown, J. Casas, A. Corvin, P. Deloukas, A. Duncanson, Janusz Jankowski, H. Markus, C. Mathew, C. Palmer, R. Plomin, A. Rautanen, S. Sawcer, R. Trembath, A. Viswanathan, N. Wood, C. Spencer, G. Band, C. Bellenguez, C. Freeman, G. Hellenthal, E. Giannoulatou, M. Pirinen, R. Pearson, A. Strange, Zhan Sul, Damjan Vukcevic, C. Langford, S. Hunt, S. Edkins, R. Gwilliam, H. Blackburn, S. Bumpstead, S. Dronov, M. Gillman, Emma V. Gray, Naomi Hammond, Alagurevathi Jayakumar, O. Mccann, J. Liddle, Simon C. Potter, Radhi Ravindrarajah, M. Ricketts, M. Waller, P. Weston, S. Widaa, P. Whittaker, Alastair Compston, D. Hafler, H. Harbo, S. Hauser, G. Stewart, S. D'alfonso, G. Hadjigeorgiou, B. E. Taylor, L. Barcellos, D. Booth, R. Hintzen, I. Kockum, F. Martinelli-Boneschi, J. McCauley, J. Oksenberg, A. Oturai, S. Sawcer, A. Ivinson, T. Olsson, P. Jager   +268 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis

Scientific Reports
Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study
Andrei Miclea, Jonathan Zurawski, Brian C. Healy, Shrishti Saxena, Hrishikesh Lokhande, Molly Quattrucci, Renxin Chu, Howard L. Weiner, Rohit Bakshi, Tanuja Chitnis   +9 more
doaj   +1 more source

Therapeutic Potential of Extracellular Vesicles for Demyelinating Diseases; Challenges and Opportunities

Frontiers in Molecular Neuroscience, 2018
Multiple Sclerosis is a demyelinating disease of the central nervous system for which no remyelination therapy is available and alternative strategies are being tested.
Iñaki Osorio-Querejeta, Iñaki Osorio-Querejeta, Ainhoa Alberro, Maider Muñoz-Culla, Maider Muñoz-Culla, Imre Mäger, Imre Mäger, David Otaegui, David Otaegui   +8 more
doaj   +1 more source

Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues

Lancet Neurology, 2020
Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a sometimes neglected, yet common, sign and symptom with a profound effect on instrumental activities of daily living.
R. Benedict, M. Amato, J. DeLuca, J. Geurts   +3 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Improving dynamic balance in relapsing-remitting MS: insights from robotic-assisted rehabilitation therapy

Journal of NeuroEngineering and Rehabilitation
Background Balance deficits affect over 75% of people with multiple sclerosis (PwMS), significantly limiting mobility and daily activities. To address these symptoms, technology-assisted rehabilitation has recently shown promise for restoring balance ...
Jessica Podda, Ludovico Pedullà, Giorgia Marchesi, Valentina Squeri, Alice De Luca, Alice Bellosta, Giulia Rogina, Andrea Vitiello, Laura Isolabella, Margherita Monti Bragadin, Mario Alberto Battaglia, Andrea Tacchino, Giampaolo Brichetto   +12 more
doaj   +1 more source

No evidence of a significant role for CTLA-4 in multiple sclerosis [PDF]

, 2006
Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore
Compston, A, Deans, J, Hensiek, A, Maranian, M, Roxburgh, R, Sawcer, S, Seaman, S, Yeo, T   +7 more
core  

Web-based physiotherapy for people affected by multiple sclerosis: a single blind, randomized controlled feasibility study [PDF]

, 2018
Objective: To examine the feasibility of a trial to evaluate web-based physiotherapy compared to a standard home exercise programme in people with multiple sclerosis. Design: Multi-centre, randomized controlled, feasibility study.
Alex McConnachie, Belinda Weller, Berg K, Brazier J, Brennan DM, Cohen J., Curtis L, Elaine H Coulter, Frevel D, Heather Murray, Jennifer Freeman, Khan F, Linda Renfrew, Lorna Paul, Olivia Wu, Paul Mattison, Robert Heggie   +16 more
core   +3 more sources