Results 1 to 10 of about 357,759 (140)

NK Cells and Innate-Like T Cells After Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Frontiers in Immunology, 2021
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, in which autoreactive T and B cells play important roles. Other lymphocytes such as NK cells and innate-like T cells appear to be involved as well.
Josefine Ruder, Jordan Rex, Simon Obahor, María José Docampo, Antonia M. S. Müller, Urs Schanz, Ilijas Jelcic, Roland Martin   +7 more
doaj   +1 more source

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

eLife, 2021
While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue ...
Sina C Rosenkranz, Artem A Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E Witte, Vanessa Roth, Vanessa Vieira, Nanne Paauw, Simone Bauer, Celina Schwencke-Westphal, Charlotte Schubert, Lukas Can Bal, Benjamin Schattling, Ole Pless, Jack van Horssen, Marc Freichel, Manuel A Friese   +16 more
doaj   +1 more source

Klotho and vitamin D in multiple sclerosis: an Italian study [PDF]

, 2020
Introduction Low vitamin D levels have been recognised as an important risk factor for autoimmune diseases, including multiple sclerosis (MS). MS is a multifactorial disease, the pathogenesis of which contributes both to genetic and environmental ...
Bruna Lo Sasso, Caterina Maria Gambino, Chiara Bellia, Concetta Scazzone, Giorgia Iacolino, Giulia Bivona, Giuseppe Salemi, Luisa Agnello, Marcello Ciaccio, Paolo Ragonese, Sabrina Realmuto   +10 more
core   +1 more source

Improving Glucocorticoid Sensitivity of Brain-Homing CD4+ T Helper Cells by Steroid Hormone Crosstalk

Frontiers in Immunology, 2022
In early multiple sclerosis (MS), an IFN-γhighGM-CSFhighIL-17low CD4+ T-cell subset termed T helper 17.1 (Th17.1) reveals enhanced capacity to infiltrate the central nervous system. Th17.1 cells express high levels of multidrug resistance protein 1 (MDR1)
Steven C. Koetzier, Steven C. Koetzier, Jamie van Langelaar, Jamie van Langelaar, Annet F. Wierenga-Wolf, Annet F. Wierenga-Wolf, Marie-José Melief, Marie-José Melief, Kim Pol, Kim Pol, Suzanne Musters, Suzanne Musters, Erik Lubberts, Willem A. Dik, Willem A. Dik, Joost Smolders, Joost Smolders, Joost Smolders, Joost Smolders, Marvin M. van Luijn, Marvin M. van Luijn   +20 more
doaj   +1 more source

Advanced imaging for multiple sclerosis (ORP-14) [PDF]

Neurology Letters, 2023
This study focuses on the use of advanced imaging techniques for the assessment of multiple sclerosis (MS). The objective is to explore the potential of these imaging modalities in providing valuable insights into the pathophysiology and characterization
Elnaz Asadollahzadeh
doaj  

Podcast on the Challenges and Recommendations to Address Unmet Needs in MS for LGBTQ+ Populations in the United States

Neurology and Therapy, 2023
In general, individuals who are lesbian, gay, bisexual, transgender, queer or questioning, plus other identities (LGBTQ+) living with multiple sclerosis (MS) have less favorable healthcare experiences and poorer overall health than cisgendered ...
William L. Conte, Mark Cascione, Amy B. Sullivan   +2 more
doaj   +1 more source

Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. [PDF]

, 2015
Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits.
Biswas, Sangita, Deng, Wenbin, Qin, Xin, Xiao, Juan, Yang, Rongbing, Zhang, Min   +5 more
core   +6 more sources

Real-World Safety and Effectiveness of Dimethyl Fumarate in Hispanic or Latino Patients with Multiple Sclerosis: 3-Year Results from ESTEEM

Neurology and Therapy, 2020
Introduction Compared with the non-Hispanic/non-Latino population, Hispanic/Latino patients with multiple sclerosis (MS) are reported to exhibit greater disease severity.
Angel Chinea, Lilyana Amezcua, Wendy Vargas, Annette Okai, Mitzi J. Williams, Ray Su, Becky Parks, Jason P. Mendoza, James B. Lewin, Cynthia C. Jones   +9 more
doaj   +1 more source

Personalised profiling to identify clinically relevant changes in tremor due to multiple sclerosis

BMC Medical Informatics and Decision Making, 2019
Background There is growing interest in sensor-based assessment of upper limb tremor in multiple sclerosis and other movement disorders. However, previously such assessments have not been found to offer any improvement over conventional clinical ...
David G. Western, Simon A. Neild, Rosemary Jones, Angela Davies-Smith   +3 more
doaj   +1 more source

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. [PDF]

, 2016
ObjectiveWe sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality.MethodsWe conducted mendelian randomization (MR ...
Alfredsson, Lars, Barcellos, Lisa F, Bäärnhielm, Maria, Gianfrancesco, Milena, Glymour, M Maria, Gyllenberg, Alexandra, Hedström, Anna Karin, Hillert, Jan, Kockum, Ingrid, Link, Jenny, Mok, Amanda, Olsson, Tomas, Quach, Hong, Rhead, Brooke, Schaefer, Catherine, Shao, Xiaorong, Shen, Ling   +16 more
core   +1 more source