Results 31 to 40 of about 357,928 (304)

Radiological Presentation of a Patient With Multiple Sclerosis and Hepatic Disorder

Case Reports in Clinical Practice, 2020
In this case study, we presented the radiological characteristics of a 43-year-old female patient diagnosed with Multiple Sclerosis (MS). Following mitoxantrone administration, she developed liver failure.
Saeideh Salehizadeh, Abdorreza Naser Moghadasi   +1 more
doaj   +1 more source

Short-term MRI measurements as predictors of EDSS progression in relapsing-remitting multiple sclerosis: grey matter atrophy but not lesions are predictive in a real-life setting [PDF]

PeerJ, 2016
Background Magnetic resonance imaging (MRI) is the best biomarker of inflammatory disease activity in relapsing remitting Multiple Sclerosis (RRMS) so far but the association with disability is weak.
Johanna von Gumberz, Mina Mahmoudi, Kim Young, Sven Schippling, Roland Martin, Christoph Heesen, Susanne Siemonsen, Jan-Patrick Stellmann   +7 more
doaj   +2 more sources

No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis [PDF]

, 2013
BACKGROUND: Mitochondrial dysfunction is an established feature of multiple sclerosis (MS). We recently described high levels of mitochondrial DNA (mtDNA) deletions within respiratory enzyme-deficient (lacking mitochondrial respiratory chain complex IV ...
Abadi A, Amy K Reeve, Brierley EJ, Broadwater L, Campbell GR, Campbell GR, Campbell GR, Campbell GR, Don J Mahad, Doug M Turnbull, Dutta R, Dutta R, Graham R Campbell, Harding AE, Horvath R, Iryna Ziabreva, Johnson MA, Krishnan KJ, Kumleh HH, Larsson NG, Mahler A, McFarland R, Murphy JL, Nociti V, Palace J, Parise G, Patte M, Rahman S, Rahman S, Reeve AK, Richard Reynolds, Sakiyama Y, Taylor RW, Verny C, Witte ME, Witte ME, Yu-Wai-Man P   +36 more
core   +2 more sources

Autoimmunity to a ribonucleoprotein drives neuron loss in multiple sclerosis models

Neurobiology of Disease, 2022
Neurodegeneration, the progressive loss or damage to neurons and axons, underlies permanent disability in multiple sclerosis (MS); yet its mechanisms are incompletely understood.
Cole D. Libner, Hannah E. Salapa, Catherine Hutchinson, Todd E. Stang, Patricia A. Thibault, S. Austin Hammond, Michael C. Levin   +6 more
doaj   +1 more source

Cognitive impairment among patients with multiple sclerosis:associations with employment and quality of life [PDF]

, 2016
OBJECTIVES To explore the relationship between cognitive impairment and conventional measures of disability in multiple sclerosis (MS), quality of life (QOL) and employment status using the brief international cognitive assessment for multiple ...
Campbell, J, Cercignani, M, Langdon, Dawn, Rashid, W   +3 more
core   +1 more source

A whole genome screen for association with multiple sclerosis in portuguese patients [PDF]

, 2003
Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association.
A. Compston, A. Sá, A. Valença, Barcellos, Callegaro, Cardon, Compston, Daniels, E. Setakis, Ebers, Goedde, Haines, I. Coelho, J. Dinis, J. Figueiredo, J. Pinto-Basto, J. Sequeiros, Kruglyak, L. Bigotte de Almeida, M. Santos, M.E. Rio, M.J. Sá, Marrosu, Olerup, P. Maciel, Poser, Risch, S. Sawcer, Sawcer, Sawcer, Setakis, Shaw, Yeo   +32 more
core   +4 more sources

Effectiveness of delayed-release dimethyl fumarate on patient-reported outcomes and clinical measures in patients with relapsing-remitting multiple sclerosis in a real-world clinical setting: PROTEC. [PDF]

, 2019
Ensaio clínico PROTEC, Protocolo nº 109MS408Abstract BACKGROUND: Patient-reported outcomes (PRO) and clinical outcomes give a broad assessment of relapsing-remitting multiple sclerosis (RRMS) disease.
Berger, T, Brambilla, L, Brochet, B, Giacomini, PS, Montalbán, X, Salgado, Salgado, AV, e outros   +5 more
core   +1 more source

Adding a subjective dimension to an ICF-based disability measure for people with multiple sclerosis: development and use of a measure for perception of disabilities [PDF]

, 2009
OBJECTIVE: The subjective dimension of disability, the perception of disability, is a dimension missing from the International Classification of Functioning, Disability and Health (ICF), and from health-related quality of life (HRQOL) instruments ...
De Keyser, J.H., de Ruiter, H., Lok, W.S., Middel, B., Reijneveld, S.A., van Dijk, J.P., Wynia, K.   +6 more
core   +2 more sources

Erythrocytes in multiple sclerosis: forgotten contributors to the pathophysiology? [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune disease characterised by lymphocytic infiltration of the central nervous system and subsequent destruction of myelin and axons. On the background of a genetic predisposition to autoimmunity, environmental triggers
Groen, Kira, Lechner-Scott, Jeannette, Maltby, Vicki E., Sanders, Katherine, Scott, Rodney J., Tajouri, Lotti   +5 more
core   +2 more sources

Understanding Magnetic Resonance Imaging in Multiple Sclerosis (UMIMS): Development and Piloting of an Online Education Program About Magnetic Resonance Imaging for People With Multiple Sclerosis

Frontiers in Neurology, 2022
BackgroundPeople with multiple sclerosis (pwMS) lack sufficient magnetic resonance imaging (MRI) knowledge to truly participate in frequently occurring MRI-related therapy decisions.
Magalie Freund, Insa Schiffmann, Insa Schiffmann, Anne Christin Rahn, Anne Christin Rahn, Declan Chard, Declan Chard, Carsten Lukas, Carsten Lukas, Jutta Scheiderbauer, Anna Sippel, Christoph Heesen, Christoph Heesen   +12 more
doaj   +1 more source