Results 51 to 60 of about 357,928 (304)

Can we prevent or treat multiple sclerosis by individualised vitamin D supply? [PDF]

, 2013
Apart from its principal role in bone metabolism and calcium homeostasis, vitamin D has been attributed additional effects including an immunomodulatory, anti-inflammatory, and possibly even neuroprotective capacity which implicates a possible role of ...
A Ascherio, A Ascherio, A Ascherio, A Boonstra, A Compston, A Döring, A Kutzelnigg, A Nylander, AD Sadovnick, AE Handel, AE Handel, AE Handel, AK Bhalla, B Banwell, B Hintzpeter, BD Mahon, BD Trapp, BR Becklund, C Almerighi, C Carlberg, C Pierrot-Deseilligny, C Veauthier, CH Polman, CJ Willer, D Buck, DA Dyment, DAF de Abreu, DG Haegert, DM Wingerchuk, DP Auer, DS Goodin, DS Meier, DW Eyles, E Garcion, E Peelen, ED Acheson, EM Mowry, EM Mowry, F Dalmay, F Mirzaei, F Paul, G Giovannoni, H Tremlett, HA Bischoff-Ferrari, HF Deluca, HF McFarland, IAF Van der Mei, IAF Van der Mei, J Aivo, J Correale, J Dörr, J Dörr, J Río, J Salzer, J Smolders, J Smolders, J Vogt, JC Fleet, JC Souberbielle, JF Kurtzke, JF Kurtzke, JF Marcus, JH White, JM Burton, JM Lemire, JM Lemire, JN Hathcock, JW Peterson, KI Løken-Amsrud, KL Munger, KL Munger, KM Spach, L Grimaldi, L Piemonti, LB Pedersen, M Bock, M Di Rosa, M Soilu-Hänninen, M Soilu-Hänninen, MD Griffin, MF Holick, MF Holick, MF Holick, MF Holick, MK Thomas, MR Haussler, MS Stein, MT Cantorna, MT Kampman, MT Kampman, N Borisow, N De Stefano, N Jain, N Weinges-Evers, O Golubnitschaja, P Goldberg, PH Hart, PS Sorensen, R Dobson, RJ Fox, RL Swank, RM Lucas, S Chen, S Simpson Jr, S Sotgiu, S Wergeland, S Yu, SM Kimball, SV Ramagopalan, SV Ramagopalan, SV Ramagopalan, SV Ramagopalan, T Hagenau, T Holmøy, T Islam, T Oberwahrenbrock, T Sinnecker, T Sinnecker, TF Runia, TY McDowell, TY McDowell, V Limmroth, V Shaygannejad, VA Jagannath, WB Grant, Y Jin, Ø Torkildsen   +126 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Factors affecting continuation of clean intermittent catheterisation in people with multiple sclerosis: results of the COSMOS mixed-methods study [PDF]

, 2018
Background:  Clean intermittent catheterisation (CIC) is often recommended for people with multiple sclerosis (MS).  Objective:  To determine the variables that affect continuation or discontinuation of the use of CIC.
Andrew Elders, Brian Buckley, Carol Bugge, Creswell JW., Doreen McClurg, Fowler CJ, Katherine N Moore, Mandy Fader, McClurg D, Naish W., Seth J, Suzanne Hagen, Tasneem Irshad, Vahter L   +13 more
core   +5 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Escalation or high-efficacy disease-modifying therapies in multiple sclerosis [PDF]

Neurology Letters, 2023
Elnaz Asadollahzadeh
doaj   +1 more source

Reliability and Validity of Ratings of Perceived Exertion in Persons With Multiple Sclerosis [PDF]

, 2016
Objective: To test the reliability and validity of using the Borg rating of perceived exertion (RPE) scale (ratings 6e20) in persons with multiple sclerosis (PwMS). Design: Nonrandomized repeated measures. Setting: Research laboratory.
Cleland, Brice T., Ingraham, Benjamin A., Ng, Alexander V., Pitluck, Molly C.   +3 more
core   +1 more source

Using IMPrESS to guide policy change in multiple sclerosis [PDF]

, 2017
The International MultiPlE Sclerosis Study (IMPrESS) studied the significant impact of multiple sclerosis (MS) on the health and well-being of both people with the disease and their caregivers, along with its broader socioeconomic impact.
Efthymiadou, Olina, Grimaccia, Federico, Kanavos, Panos, Mossman, Jean, Tinelli, Michela, Visintin, Erica   +5 more
core   +2 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

The Impact of Cognitive Functioning on Daily Occupations for People with Multiple Sclerosis: A Qualitative Study [PDF]

, 2019
Background: Cognitive rehabilitation research in multiple sclerosis is ever-developing, but the impact of cognitive difficulties, seen in 40% to 80% of people, on daily occupations is not well known.
Hynes, Sinéad M, Mc Auliffe, Aoife
core   +1 more source