Results 41 to 50 of about 357,928 (304)

A Case of Multiple Sclerosis Presenting as Eight and Half Syndrome. [PDF]

, 2013
Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, gliosis (scarring), and neuronal loss; the course can be relapsing-remitting or progressive.
Kaushik, M, Mahajan, SK, Raghav, S, Raina, R, Sharathbabu, NM   +4 more
core  

The use of multiple sclerosis condition-specific measures to inform health policy decision-making: mapping from the MSWS-12 to the EQ-5D [PDF]

, 2012
The final version of this paper has been published in Multiple Sclerosis, 18 (6), June 2012 by SAGE Publications Ltd, All rights reserved. © It is available at: http:// msj.sagepub.com/Walking impairment has a major influence on the quality of life of ...
Brazier J, Canadian Agency for Drugs and Technologies in Health (CADTH), Crott R, EuroQol Group, Fischer J, Glick H, Gold M, Long J, National Institute for Health and Clinical Excellence, Pharmaceutical Benefits Advisory Committee, Round J, Royal College of Physicians MT, US Department of Health and Human Services Food and Drug Administration   +12 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation

Frontiers in Cellular Neuroscience, 2020
Microglia are central nervous system (CNS) resident immune cells that have been implicated in neuroinflammatory pathogenesis of a variety of neurological conditions.
Alex R. D. Delbridge, Alex R. D. Delbridge, Dann Huh, Margot Brickelmaier, Jeremy C. Burns, Chris Roberts, Ravi Challa, Naideline Raymond, Patrick Cullen, Thomas M. Carlile, Katelin A. Ennis, Mei Liu, Chao Sun, Normand E. Allaire, Marianna Foos, Hui-Hsin Tsai, Nathalie Franchimont, Richard M. Ransohoff, Cherie Butts, Michael Mingueneau   +19 more
doaj   +1 more source

An interactive web-based programme on relapse management for people with multiple sclerosis (POWER@MS2) - development, feasibility, and pilot testing of a complex intervention

Frontiers in Neurology, 2022
IntroductionDespite the lack of high-quality evidence regarding its long-term effectiveness, intravenous corticosteroid therapy is recommended as the standard treatment of acute multiple sclerosis relapses in Germany.
Lisa Wenzel, Lisa Wenzel, Christoph Heesen, Christoph Heesen, Julia Peper, Kristina Grentzenberg, Edeltraud Faßhauer, Jutta Scheiderbauer, Frithjof Thale, Björn Meyer, Sascha Köpke, Anne Christin Rahn, Anne Christin Rahn   +12 more
doaj   +1 more source

Wellness and Multiple Sclerosis: The National MS Society Establishes a Wellness Research Working Group and Research Priorities [PDF]

, 2017
Background: People with multiple sclerosis (MS) have identified “wellness” and associated behaviors as a high priority based on “social media listening” undertaken by the National MS Society (i.e. the Society). Objective: The Society recently convened a
Bishop, Malachy, Casaccia, Patrizia, Chiaravalloti, Nancy D., Costello, Kathleen, Ehde, Dawn M., Fernhall, Bo, Geisser, Barbara, LaRocca, Nicholas G., McCully, Kevin K., Motl, Robert W., Mowry, Ellen M., Ng, Alex V., Plow, Matthew, Shinto, Lynne, Smith, Kathy E., Sullivan, Amy B.   +15 more
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Patient level dataset to study the effect of COVID-19 in people with Multiple Sclerosis

Scientific Data
Multiple Sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system, causing increased vulnerability to infections and disability among young adults. Ever since the outbreak of coronavirus disease 2019 (COVID-19), caused by severe
Hamza Khan, Lotte Geys, Peer Baneke, Giancarlo Comi, Liesbet M. Peeters   +4 more
doaj   +1 more source