Results 41 to 50 of about 6,788,532 (255)

The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study.

PLoS ONE, 2011
BackgroundIn the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from
International Multiple Sclerosis Genetics Consortium
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Pregnancy-Induced Changes in microRNA Expression in Multiple Sclerosis

Frontiers in Immunology, 2021
Pregnancy affects the disease course in multiple sclerosis (MS), particularly in the third trimester, where the relapse rate is reduced by as much as two thirds.
Helle Bach Søndergaard, Laura Airas, Jeppe Romme Christensen, Birgitte Romme Nielsen, Lars Börnsen, Annette Oturai, Finn Sellebjerg   +6 more
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Emerging immunopharmacological targets in multiple sclerosis. [PDF]

, 2015
Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals worldwide. It has been widely accepted, although not proven, that the
Abdolmohamad Rostami, Abrams, Abrams, Achiron, Adelman, Allen, Bachmann, Bai, Bai, Baker, Balcer, Bar-Or, Bar-Or, Bar-Or, Bar-Or, Ben-Nun, Biasi, Bielekova, Bielekova, Bielekova, Bielekova, Bielekova, Bitar, Bluestone, Bogoljub Ciric, Bour-Jordan, Bourdette, Bourquin, Brambilla, Brocke, Burman, Burns, Burrows, Chaudhuri, Chitnis, Coles, Constantinescu, Constantinescu, Correale, Correale, Cox, Cragg, Crowe, Darlington, Darlington, Disanto, Duddy, Emery, Espinoza-Delgado, Faria, Faria, Farjam, Feinstein, Fissolo, Fletcher, Freedman, Garren, Garren, Garren, Garren, Giovannoni, Giovannoni, Girvin, Girvin, Goodin, Gosselin, Goverman, Goverman, Guang-Xian Zhang, Hale, Hartmann, Hauser, Havrdova, Hawker, He, Hedegaard, Higgins, Hill-Cawthorne, Hilliard, Hilliard, Ho, Hoffmann, Hofman, Jankovic, Jennum, Kappos, Kappos, Karussis, Karussis, Kearney, Kerbrat, Le Page, Li, Liblau, Lider, Lider, Lindsey, Lindsey, Lisak, Liu, Lobell, Lobell, Lohse, Lund, Lyons, Marrie, Marta, Martin, Mease, Medaer, Mestecky, Mikulkova, Miller, Milo, Mirshafiey, Mojtaba Farjam, Moreau, Mowat, Nicoletti, Nightingale, O'Brien, Offner, Offner, Oh, Oksenberg, Pender, Pettitt, Phillips, Phillips, Podojil, Poli, Pozzilli, Pryce, Quintana, Racioppi, Rasouli, Robinson, Rose, Rose, Rostami, Sandrini, Schaub, Sclerosis, Selmaj, Selmaj, Sinha, Smith, Spuler, Stuve, Taoufik, Tsunoda, Turley, Turley, Turner, van Boxel-Dezaire, van den Hoogen, Van der Walt, van Oosten, van Oosten, van Oosten, Vandenbark, Vandenbark, Viglietta, Viglietta, Vollmer, Walczak, Waldmann, Wang, Weber, Wefer, Weiner, Weiner, Weissert, Willis, Wucherpfennig, Wynn, Xing, Yadav, Zang, Zhang, Zhang, Zhang, Zhang   +182 more
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A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

Nature Communications, 2019
Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights ...
International Multiple Sclerosis Genetics Consortium
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Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals

Immunity & Ageing, 2023
Background Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification is essential to prevent dependence. Several molecules have been proposed as biomarkers of frailty, but none of them have
Leire Iparraguirre, Ainhoa Alberro, Saioa GS Iñiguez, Maider Muñoz-Culla, Itziar Vergara, Ander Matheu, David Otaegui   +6 more
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Treating Systematic Errors in Multiple Sclerosis Data [PDF]

, 2005
Multiple sclerosis (MS) is characterized by high variability between patients and, more importantly here, within an individual over time. This makes categorization and prognosis difficult.
Confavreux, C., Daumer, Martin, Ebers, G. C., Heigenhauser, L., Kappos, L., Lederer, C., Neiß, A., Polman, C., Vukusic, S.   +8 more
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Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models

NeuroImage: Clinical, 2015
Magnetic resonance imaging (MRI) of the brain provides important outcome measures in the longitudinal evaluation of disease activity and progression in MS subjects. Two common measures derived from brain MRI scans are the brain parenchymal fraction (BPF)
Alicia S. Chua, MS, Svetlana Egorova, MD, PhD, Mark C. Anderson, MS, Mariann Polgar-Turcsanyi, MS, Tanuja Chitnis, MD, Howard L. Weiner, MD, Charles R.G. Guttmann, MD, Rohit Bakshi, MD, Brian C. Healy, PhD   +8 more
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Reduction in circulating vitamin D binding protein in patients with multiple sclerosis

BMC Neurology, 2021
Background In this study, we aimed to determine the risk association between vitamin D binding protein (VDBP) polymorphism in patients with multiple sclerosis (MS) in a MS biobank and the difference in VDBP serum levels in MS patients who were recently ...
Zhila Maghbooli, Abolfazl Omidifar, Tarlan Varzandi, Tayebeh Salehnezhad, Mohammad Ali Sahraian   +4 more
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The Role of Microorganisms in the Etiopathogenesis of Demyelinating Diseases

Life, 2023
Multiple sclerosis (MS), neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) are inflammatory diseases of the central nervous system (CNS) with a multifactorial aetiology.
Jessica Frau, Giancarlo Coghe, Lorena Lorefice, Giuseppe Fenu, Eleonora Cocco   +4 more
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Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination [PDF]

, 2017
Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage.
Bramlett, Brück, Brück, Clark, Cunningham, Foote, Fünfschilling, Gudi, Hiremath, Hiremath, Irvine, Irvine, Kornek, Kuhlmann, Kutzelnigg, Lassmann, Lassmann, Lee, Lindner, Lindner, Lucchinetti, Manrique-Hoyos, Mason, Matsushima, McKenzie, Mildner, Morrison, Murray, Nikic, Otsuka, Patrikios, Pierce, Schuh, Simons, Singh, Skripuletz, Sorbara, Stidworthy, Trapp   +38 more
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