Results 41 to 50 of about 458,215 (302)

Cerebrospinal fluid ATP metabolites in multiple sclerosis

, 2010
Increased axonal energy demand and mitochondrial failure have been suggested as possible causes for axonal degeneration and disability in multiple sclerosis.Our objective was to test whether ATP depletion precedes clinical, imaging and biomarker evidence
Uitdehaag, BMJ, Di Pietro, V., Barkhof, F., Killestein, J, Belli, A.; id_orcid, Killestein, J., Uitdehaag, B.M.J., Eikelenboom, M.J., University of Catania, Tavazzi, B, Petzold, A.F.S., Petzold, A., Petzold, A, Belli, A., Eikelenboom, MJ, Lazzarino, G., Lazzarino, G, Di Pietro, V, Polman, CH, Amorini, A.M., Barkhof, F, Tavazzi, B., Polman, C.H., Belli, A, Di Pietro, V.; id_orcid, Amorini, AM, Pietro, V. Di   +26 more
core   +1 more source

Multiple sclerosis

Disease-a-Month, 1996
Multiple sclerosis is a chronic disease that begins in late adolescence or adulthood. It is highly variable in its expression and severity. It is believed to be autoimmune in nature. The cause is unknown; both genetic and environmental factors have been implicated in the pathogenesis. MS generally presents with the acute or subacute onset of neurologic
Lynch, Sharon G., Rose, John W.
openaire   +2 more sources

The possible role of Interleukin-6 as a regulator of insulin sensitivity in patients with neuromyelitis optica spectrum disorder

BMC Neurology, 2021
Background Neuromyelitis optica spectrum disorder (NMOSD) is associated with inflammatory mediators that may also trigger downstream signaling pathways leading to reduce insulin sensitivity.
Zhila Maghbooli, Abdorreza Naser Moghadasi, Nasim Rezaeimanesh, Abolfazl Omidifar, Tarlan Varzandi, Mohammad Ali Sahraian   +5 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Risk of fractures in patients with multiple sclerosis: a population-based cohort study. [PDF]

, 2012
OBJECTIVE: To examine the risk of fracture in patients with multiple sclerosis (MS) compared with population-based controls. METHODS: A population-based cohort study was performed in the Dutch PHARMO Record Linkage System (1998-2008). Patients with MS (n
Van Staa, Tjeerd; id_orcid, Uitdehaag, BMJ, van Staa, T.P., Vries, F. de, van Staa, TP, Vestergaard, P, Herings, R.M., Leufkens, HGM, de Vries, F, Herings, RM, Staa, TP van, Uitdehaag, B M J, Herings, R M C, Leufkens, H.G.M., Uitdehaag, B.M.J., Cooper, Cyrus, van Staa, Tjeerd P., Herings, Ron M. C., Leufkens, H.G., Bazelier, MT, Dobson, R, Uitdehaag, Bernard M. J., Bazelier, M.T., Leufkens, H G M, Leufkens, HG, Ramagopalan, S, Cooper, C., Herings, R.M.C., Leufkens, Hubertus G. M., Cooper, C, Uitdehaag, BM, Bazelier, M T, de Vries, F., van Staa, T-P, Vestergaard, P., Herings, RMC, Giovannoni, G, Bazelier, Marloes T., Uitdehaag, B.M., de Vries, F.; id_orcid   +39 more
core   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Improving dynamic balance in relapsing-remitting MS: insights from robotic-assisted rehabilitation therapy

Journal of NeuroEngineering and Rehabilitation
Background Balance deficits affect over 75% of people with multiple sclerosis (PwMS), significantly limiting mobility and daily activities. To address these symptoms, technology-assisted rehabilitation has recently shown promise for restoring balance ...
Jessica Podda, Ludovico Pedullà, Giorgia Marchesi, Valentina Squeri, Alice De Luca, Alice Bellosta, Giulia Rogina, Andrea Vitiello, Laura Isolabella, Margherita Monti Bragadin, Mario Alberto Battaglia, Andrea Tacchino, Giampaolo Brichetto   +12 more
doaj   +1 more source

Therapeutic Potential of Extracellular Vesicles for Demyelinating Diseases; Challenges and Opportunities

Frontiers in Molecular Neuroscience, 2018
Multiple Sclerosis is a demyelinating disease of the central nervous system for which no remyelination therapy is available and alternative strategies are being tested.
Iñaki Osorio-Querejeta, Iñaki Osorio-Querejeta, Ainhoa Alberro, Maider Muñoz-Culla, Maider Muñoz-Culla, Imre Mäger, Imre Mäger, David Otaegui, David Otaegui   +8 more
doaj   +1 more source