Results 31 to 40 of about 458,215 (302)

The Role of Microorganisms in the Etiopathogenesis of Demyelinating Diseases

Life, 2023
Multiple sclerosis (MS), neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) are inflammatory diseases of the central nervous system (CNS) with a multifactorial aetiology.
Jessica Frau, Giancarlo Coghe, Lorena Lorefice, Giuseppe Fenu, Eleonora Cocco   +4 more
doaj   +1 more source

A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

Nature Communications, 2019
Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights ...
International Multiple Sclerosis Genetics Consortium
doaj   +1 more source

Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals

Immunity & Ageing, 2023
Background Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification is essential to prevent dependence. Several molecules have been proposed as biomarkers of frailty, but none of them have
Leire Iparraguirre, Ainhoa Alberro, Saioa GS Iñiguez, Maider Muñoz-Culla, Itziar Vergara, Ander Matheu, David Otaegui   +6 more
doaj   +1 more source

Designing a Self-Perception Cognitive Questionnaire for Italian Multiple Sclerosis Patients (Sclerosi Multipla Autovalutazione Cognitiva, SMAC). A Preliminary Exploratory Pilot Study

Frontiers in Neurology, 2021
Background: Although cognition in multiple sclerosis (MS) is assessed by means of several neuropsychological tests, only a few tools exist to investigate patients' perspectives on cognitive functioning.Objective: To develop a new questionnaire aimed at ...
Alice Riccardi, Francesca Ognibene, Sara Mondini, Massimo Nucci, Monica Margoni, Ilaria Meglioranzi, Elisa Carta, Sofia Zywicki, Silvia Miante, Paola Perini, Francesca Rinaldi, Marco Puthenparampil, Paolo Gallo   +12 more
doaj   +1 more source

Functional clinical outcomes in multiple sclerosis: Current status and future prospects [PDF]

, 2015
For decades, the Expanded Disability Status Scale (EDSS) has been the principal measure of disability in clinical trials in patients with multiple sclerosis (MS) and in clinical practice.
Deleu, Dirk T., Dahdaleh, Maurice P., Alroughani, Raed, Inshasi, Jihad Said, Yamout, Bassem I., Bohlega, Saeed A., Sahraian, Mohammed A., AlTahan, Abdulrahman M., Rieckmann, Peter, Al-Jumah, Mohammed A., Alsharoqi, Isa Ahmed, Deleu, Dirk, Aljumah, Mohammed, Daif, Abdulkader Kader M., Karabudak, Rana, Alroughani, Raed A., Sahraian, Mohammad Ali, Inshasi, Jihad S., Dahdaleh, Maurice, Alsharoqi, I. Ahmed, Amous, Amer, Daif, Abdulkader   +21 more
core   +1 more source

Multiple sclerosis [PDF]

Primary Care: Clinics in Office Practice, 2004
Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS.
Kathleen, Hawker, Elliot, Frohman
openaire   +4 more sources

Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models

NeuroImage: Clinical, 2015
Magnetic resonance imaging (MRI) of the brain provides important outcome measures in the longitudinal evaluation of disease activity and progression in MS subjects. Two common measures derived from brain MRI scans are the brain parenchymal fraction (BPF)
Alicia S. Chua, MS, Svetlana Egorova, MD, PhD, Mark C. Anderson, MS, Mariann Polgar-Turcsanyi, MS, Tanuja Chitnis, MD, Howard L. Weiner, MD, Charles R.G. Guttmann, MD, Rohit Bakshi, MD, Brian C. Healy, PhD   +8 more
doaj   +1 more source

Multiple sclerosis [PDF]

Mental Health Clinician, 2019
Abstract Multiple sclerosis is a chronic, unpredictable, and disabling disease. Significant advances have been made in recent years supporting an earlier, more accurate, diagnosis and have led to more than 15 disease-modifying therapies approved by the Food and Drug Administration for relapsing forms of multiple sclerosis.
Shilpa Klocke, Nicole Hahn
openaire   +2 more sources

Reduction in circulating vitamin D binding protein in patients with multiple sclerosis

BMC Neurology, 2021
Background In this study, we aimed to determine the risk association between vitamin D binding protein (VDBP) polymorphism in patients with multiple sclerosis (MS) in a MS biobank and the difference in VDBP serum levels in MS patients who were recently ...
Zhila Maghbooli, Abolfazl Omidifar, Tarlan Varzandi, Tayebeh Salehnezhad, Mohammad Ali Sahraian   +4 more
doaj   +1 more source

Experience of Identity Change in People Who Reported a Diagnosis of Multiple Sclerosis : A Qualitative Inquiry

, 2019
Background: A diagnosis of multiple sclerosis (MS) can lead to changes to a person’s sense of self. The aim of this study was to investigate the subjective experience of identity change and subsequent adjustment to MS.
das Nair, Roshan, Smale, Kathryn, Lincoln, NB, Lincoln, Nadina B., Barker, AB, Hunt, N, Smale, K., das Nair, R, Hunt, Nigel, Barker, Alexander B., Barker, A., Smale, K, Lincoln, N.B., Hunt, N.   +13 more
core   +1 more source