Results 11 to 20 of about 372,299 (218)

Family Perspectives on Clinical Research for Pediatric Multiple Sclerosis: Enhancing Equity

Journal of Patient Experience, 2021
Pediatric new drug trials are federally mandated, but family perspectives in multiple sclerosis (MS) research are limited. Due to MS chronicity and long-term medical system involvement, we obtained family views on research priorities and optimized ...
Leslie A Mandel PhD, MA, MS, Ellen O’Donnell PhD, Katia Canenguez PhD, EdM, Paola B Castro-Mendoza BSc, MSc, Tim Lotze MD, Emmanuelle Waubant MD, PhD, Bianca Weinstock-Guttmann MD, Tanuja Chitnis MD   +7 more
doaj   +1 more source

Results of treatment with alemtuzumab in a Spanish cohort of patients with multiple sclerosis in the real world: The RealMS study

Frontiers in Neurology, 2023
BackgroundAlemtuzumab (ALZ) is a humanized monoclonal antibody approved for the treatment of patients with highly active relapsing-remitting multiple sclerosis (RRMS) administered in two annual courses.
Sara Eichau, Rocío López Ruiz, María Ruíz de Arcos, Juan Luis Ruiz-Peña, Guillermo Navarro, Miguel Ángel Calleja, José Luis Moreno-Amador, Julio Dotor García-Soto   +7 more
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The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study.

PLoS ONE, 2011
BackgroundIn the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from
International Multiple Sclerosis Genetics Consortium
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Standard versus innovative robotic balance assessment for people with multiple sclerosis: a correlational study

European Journal of Medical Research, 2023
Introduction Balance disorders are common in people with Multiple Sclerosis (PwMS) and, together with other impairments and disabilities, often prevent PwMS from performing their daily living activities.
Jessica Podda, Giorgia Marchesi, Valentina Squeri, Alice De Luca, Alice Bellosta, Ludovico Pedullà, Giovanna Konrad, Mario Alberto Battaglia, Giampaolo Brichetto, Andrea Tacchino   +9 more
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A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

Nature Communications, 2019
Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights ...
International Multiple Sclerosis Genetics Consortium
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Designing a Self-Perception Cognitive Questionnaire for Italian Multiple Sclerosis Patients (Sclerosi Multipla Autovalutazione Cognitiva, SMAC). A Preliminary Exploratory Pilot Study

Frontiers in Neurology, 2021
Background: Although cognition in multiple sclerosis (MS) is assessed by means of several neuropsychological tests, only a few tools exist to investigate patients' perspectives on cognitive functioning.Objective: To develop a new questionnaire aimed at ...
Alice Riccardi, Francesca Ognibene, Sara Mondini, Massimo Nucci, Monica Margoni, Ilaria Meglioranzi, Elisa Carta, Sofia Zywicki, Silvia Miante, Paola Perini, Francesca Rinaldi, Marco Puthenparampil, Paolo Gallo   +12 more
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Interleukin-33 plasma levels in patients with relapsing-remitting multiple sclerosis

Biomolecular Concepts, 2017
Cytokines are implicated in the immunopathogenesis of multiple sclerosis (MS). Interleukin (IL)-33, one of the recently discovered members of the IL-1 superfamily, is a dual functional cytokine involved in various autoimmune disorders.
Alsahebfosoul Fereshteh, Rahimmanesh Ilnaz, Shajarian Mansour, Etemadifar Masoud, Sedaghat Nahid, Hejazi Zahra, Naderi Shamsi   +6 more
doaj   +1 more source

Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals

Immunity & Ageing, 2023
Background Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification is essential to prevent dependence. Several molecules have been proposed as biomarkers of frailty, but none of them have
Leire Iparraguirre, Ainhoa Alberro, Saioa GS Iñiguez, Maider Muñoz-Culla, Itziar Vergara, Ander Matheu, David Otaegui   +6 more
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Pregnancy-Induced Changes in microRNA Expression in Multiple Sclerosis

Frontiers in Immunology, 2021
Pregnancy affects the disease course in multiple sclerosis (MS), particularly in the third trimester, where the relapse rate is reduced by as much as two thirds.
Helle Bach Søndergaard, Laura Airas, Jeppe Romme Christensen, Birgitte Romme Nielsen, Lars Börnsen, Annette Oturai, Finn Sellebjerg   +6 more
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Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models

NeuroImage: Clinical, 2015
Magnetic resonance imaging (MRI) of the brain provides important outcome measures in the longitudinal evaluation of disease activity and progression in MS subjects. Two common measures derived from brain MRI scans are the brain parenchymal fraction (BPF)
Alicia S. Chua, MS, Svetlana Egorova, MD, PhD, Mark C. Anderson, MS, Mariann Polgar-Turcsanyi, MS, Tanuja Chitnis, MD, Howard L. Weiner, MD, Charles R.G. Guttmann, MD, Rohit Bakshi, MD, Brian C. Healy, PhD   +8 more
doaj   +1 more source