Results 51 to 60 of about 458,215 (302)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis

open access: yesScientific Reports
Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study
Andrei Miclea   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Profile and burden of the family caregiver: the caring experience in multiple sclerosis. An observational study

open access: yesBMC Psychology
Background The broad implications of caring for a family member with a chronic medical condition, such as MS, can lead caregivers to experience a high burden of care.
Michela Ponzio   +5 more
doaj   +1 more source

The association of selected multiple sclerosis symptoms with disability and quality of life: a large Danish self-report survey

open access: yesBMC Neurology, 2021
Background People with multiple sclerosis (MS) experience a wide range of unpredictable and variable symptoms. The symptomatology of MS has previously been reported in large sample registry studies; however, some symptoms may be underreported in ...
S. Gustavsen   +6 more
doaj   +1 more source

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis [PDF]

open access: yes, 2013
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10−4).
International Ibd Genetics Consortium   +999 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Myelin-specific IL2 + T-cells are associated with last occurring relapse severity in relapsing–remitting multiple sclerosis

open access: yesScientific Reports
Autoreactive T-cells against myelin are implicated in multiple sclerosis (MS) however, the functional relevance of IL2-producing central memory T-cells and IFNɣ-producing effector T-cells have not been assessed.
Rina Zilkha-Falb   +3 more
doaj   +1 more source

A grounded theory analysis of the occupational impact of caring for a partner who has multiple sclerosis [PDF]

open access: yes, 2006
Chronic progressive conditions such as multiple sclerosis impact engagement in and orchestration of daily occupations by people with the condition, and their family members.
Molineaux, M   +7 more
core   +1 more source

Serum neurofilament light and MRI predictors of cognitive decline in patients with secondary progressive multiple sclerosis: Analysis from the MS-STAT randomised controlled trial [PDF]

open access: yes, 2022
Magnetic resonance imaging; Neurofilament light; Secondary progressive multiple sclerosisImatge per ressonància magnètica; Llum del neurofilament; Esclerosi múltiple secundària progressivaImagen por resonancia magnética; Luz de neurofilamento; Esclerosis
Doshi, Anisha   +5 more
core   +1 more source

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