Results 51 to 60 of about 459,966 (302)

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Risk of fractures in patients with multiple sclerosis: a population-based cohort study. [PDF]

, 2012
OBJECTIVE: To examine the risk of fracture in patients with multiple sclerosis (MS) compared with population-based controls. METHODS: A population-based cohort study was performed in the Dutch PHARMO Record Linkage System (1998-2008). Patients with MS (n
Van Staa, Tjeerd; id_orcid, Uitdehaag, BMJ, van Staa, T.P., Vries, F. de, van Staa, TP, Vestergaard, P, Herings, R.M., Leufkens, HGM, de Vries, F, Herings, RM, Staa, TP van, Uitdehaag, B M J, Herings, R M C, Leufkens, H.G.M., Uitdehaag, B.M.J., Cooper, Cyrus, van Staa, Tjeerd P., Herings, Ron M. C., Leufkens, H.G., Bazelier, MT, Dobson, R, Uitdehaag, Bernard M. J., Bazelier, M.T., Leufkens, H G M, Leufkens, HG, Ramagopalan, S, Cooper, C., Herings, R.M.C., Leufkens, Hubertus G. M., Cooper, C, Uitdehaag, BM, Bazelier, M T, de Vries, F., van Staa, T-P, Vestergaard, P., Herings, RMC, Giovannoni, G, Bazelier, Marloes T., Uitdehaag, B.M., de Vries, F.; id_orcid   +39 more
core   +1 more source

Improving dynamic balance in relapsing-remitting MS: insights from robotic-assisted rehabilitation therapy

Journal of NeuroEngineering and Rehabilitation
Background Balance deficits affect over 75% of people with multiple sclerosis (PwMS), significantly limiting mobility and daily activities. To address these symptoms, technology-assisted rehabilitation has recently shown promise for restoring balance ...
Jessica Podda, Ludovico Pedullà, Giorgia Marchesi, Valentina Squeri, Alice De Luca, Alice Bellosta, Giulia Rogina, Andrea Vitiello, Laura Isolabella, Margherita Monti Bragadin, Mario Alberto Battaglia, Andrea Tacchino, Giampaolo Brichetto   +12 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Assessment of Multiple Aspects of Upper Extremity Function Independent From Ambulation in Patients With Multiple Sclerosis [PDF]

, 2023
BACKGROUND Upper extremity function (UEF) is often compromised in multiple sclerosis (MS), although its importance is regularly underrecognized relative to ambulation.
Uitdehaag, Bernard M J, Dorn, Jonas, D'Souza, Marcus, Marcus D’Souza, Ludwig Kappos, Kamm, Christian P, Jonas Dorn, Bernard M.J. Uitdehaag, Dahlke, Frank, Kappos, Ludwig, Saskia Steinheimer, Diederich, Manuela, Jessica, Burggraaff, Christian P. Kamm, Frank Dahlke, Walsh, Lorcan, Steinheimer, Saskia, van Munster, Caspar E P, Burggraaff Jessica, Lorcan Walsh, Caspar E.P. van Munster, Manuela Diederich   +21 more
core   +1 more source

Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis

Scientific Reports
Gray matter demyelinating lesions, brain atrophy and meningeal inflammation are hypothesized to be relevant in multiple sclerosis (MS) disease pathogenesis, though their relationship to immune alterations in early MS is not well characterized. This study
Andrei Miclea, Jonathan Zurawski, Brian C. Healy, Shrishti Saxena, Hrishikesh Lokhande, Molly Quattrucci, Renxin Chu, Howard L. Weiner, Rohit Bakshi, Tanuja Chitnis   +9 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Therapeutic Potential of Extracellular Vesicles for Demyelinating Diseases; Challenges and Opportunities

Frontiers in Molecular Neuroscience, 2018
Multiple Sclerosis is a demyelinating disease of the central nervous system for which no remyelination therapy is available and alternative strategies are being tested.
Iñaki Osorio-Querejeta, Iñaki Osorio-Querejeta, Ainhoa Alberro, Maider Muñoz-Culla, Maider Muñoz-Culla, Imre Mäger, Imre Mäger, David Otaegui, David Otaegui   +8 more
doaj   +1 more source

Multiple sclerosis

Disease-a-Month, 1996
Multiple sclerosis is a chronic disease that begins in late adolescence or adulthood. It is highly variable in its expression and severity. It is believed to be autoimmune in nature. The cause is unknown; both genetic and environmental factors have been implicated in the pathogenesis. MS generally presents with the acute or subacute onset of neurologic
Lynch, Sharon G., Rose, John W.
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source