Results 181 to 190 of about 372,299 (218)

EBV-driven Gate-License-Amplify circuit in multiple sclerosis pathogenesis. [PDF]

Signal Transduct Target Ther
Li Y, Shi X, Zhang Y, Zeng MS, Zhong Q, Liu W.   +5 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis. [PDF]

Acta Physiol (Oxf)
Kazanis I, Silva ME, de la Fuente AG, de Castro F, Rivera FJ.   +4 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

The Prognostic Value of Paramagnetic Rim Lesions in People With Multiple Sclerosis. [PDF]

Neurology
Lauerer M, Voon CC, McGinnis J, Sepp D, Meineke J, Wiltgen T, Berg RC, Preibisch C, Wiestler B, Engl C, Uibel P, Berthele A, Kirschke JS, Hemmer B, Mühlau M.   +14 more
europepmc   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Vertical saccadic slowing is associated with fatigue in multiple sclerosis. [PDF]

Fatigue
Ruiz-Ortiz M, García-Cena C, Hernández-Ramírez R, Moreno-García S, Labiano-Fontcuberta A, García-Bellido Ruiz S, Petronila-Cubas C, Guzmán-Villamarín DE, Benito-León J.   +8 more
europepmc   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

IgA Deficiency Exacerbates an Animal Model of Multiple Sclerosis Induced with Theiler's Virus. [PDF]

Cells
Sato F, Hinay AA, Omura S, Ahmad I, Rimal S, Nguyen CT, Park AM, Shiro R, Tsuji-Kawahara S, Tsunoda I.   +9 more
europepmc   +1 more source

Cognitive dysfunction and multiple sclerosis. [PDF]

CMAJ
Freedman DE, Feinstein A.
europepmc   +1 more source