Results 191 to 200 of about 458,215 (302)

Adaptive or Maladaptive Fear of Falling in Multiple Sclerosis: What Are We Overlooking? [PDF]

J Frailty Sarcopenia Falls
Abou L.
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Inner Plexiform Layer Microstructure Is Altered in Multiple Sclerosis. [PDF]

Invest Ophthalmol Vis Sci
Emfietzoglou M, Correa VSMC, Sakuno G, Frances S, Bantounou MA, Baroutis KG, Papadopoulos D, Charonis A, Vavvas DG.   +8 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

PET imaging of microglial pathology in multiple sclerosis. [PDF]

Curr Opin Neurol
Hartiala O, Tuomaala J, Airas L.
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Structure-function multilayer network integration and cognition in multiple sclerosis. [PDF]

Netw Neurosci
Breedt LC, Pontillo G, Santos FAN, Vriend C, Prados F, Wink AM, Bisecco A, Cagol A, Calabrese M, Castellaro M, Collorone S, Cortese R, De Stefano N, Enzinger C, Filippi M, Foster MA, Gallo A, Gonzalez-Escamilla G, Granziera C, Groppa S, Høgestøl EA, Llufriu S, Martinez-Heras E, Solana E, Messina S, Moccia M, Nygaard GO, Palace J, Pinter D, Rocca MA, Toosy A, Valsasina P, Ciccarelli O, Strijbis EM, Barkhof F, Schoonheim MM, Douw L, MAGNIMS study group.   +37 more
europepmc   +1 more source

Positron emission tomography imaging in multiple sclerosis highlights a diffuse inflammatory response in brain that appears normal on conventional magnetic resonance imaging [PDF]

, 2015
Rabiner, EA, Datta, G, Gunn, R, Ribeiro, AS, Ciccarelli, O, Nicholas, R, Yaldizli, O, Wall, MB, Matthews, PM, Scott, G, Stefano, ND, Battaglini, M   +11 more
core  

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source