Results 111 to 120 of about 421,641 (311)

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

The Multiple Sclerosis Summit: A Critical Appraisal to Improve the Management of MS [PDF]

, 2011
Kathleen Costello, Halper, Gail Hartley, Amanda Kershaw, Julie Johnson, Veronda Smith, June Halper, Heidi Maloni, Jennifer Smrtka, Tracy Walker, Joseph D'onofrio, Frank Marino, J Fletcher, S Lalor, C Sweeney, N Tubridy, K Mills, J Mcelroy, J Oksenberg, C Pierrot-Deseilligny, J Souberbielle, A Tselis, L Durelli, P Barbero, M Bergui, L Prosperini, G Borriello, De Giglio, L Leonardi, L Barletta, V Pozzilli, C, C Caon, M Din, Ching Tselis, A Lisak, R Khan, O, A Gajofatto, P Bacchetti, B Grimes, A High, E Waubant, A Carra, P Onaha, G Luetic, C Polman, O' Connor, P Havrdova, E, N Putzki, O Yaldizli, M Maurer, S Belachew, R Phan-Ba, E Bartholome, T Castillo-Trivino, E Mowry, A Gajofatto, L Kappos, E Radue, O' Connor, P, P O'connor, R Kinkel, M Kremenchutzky, G Comi, M Filippi, F Barkhof, C Polman, L Kappos, M Freedman, L Kappos, C Polman, M Freedman, R Rubin, M Namey, K Costello, P Kennedy, J Scanzillo, E Sabate, V Devonshire, Y Lapierre, R Macdonell, K Treadaway, G Cutter, A Salter, S Steinberg, R Faris, C Chang, A Chan, M Tankersley, R Halpern, S Agarwal, C Dembek, L Borton, M Lopez-Bresnahan, M Reynolds, R Stephen, C Seaman   +99 more
openalex   +1 more source

Cognitive rehabilitation and mindfulness reduce cognitive complaints in multiple sclerosis (REMIND-MS): A randomized controlled trial [PDF]

, 2023
Ilse M. Nauta, Dirk Bertens, Luciano Fasotti, Jay L.P. Fieldhouse, Bernard M.J. Uitdehaag, Roy P. C. Kessels, Anne E.M. Speckens, Brigit A. de Jong   +7 more
openalex   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

The gut-brain-axis one year after treatment with cladribine tablets in patients with relapsing remitting multiple sclerosis: a pilot study

Frontiers in Immunology
IntroductionCladribine tablets are an effective treatment for relapsing remitting multiple sclerosis (RRMS). However, almost half of the treated patients are not free of disease activity after two years.
Jeske van Pamelen, Jeske van Pamelen, Carla Rodriguez-Mogeda, Lynn van Olst, Susanne M. A. van der Pol, Maarten L. Boon, Janet de Beukelaar, Oliver H. H. Gerlach, Oliver H. H. Gerlach, Andries E. Budding, Joep Killestein, Helga E. de Vries, Leo H. Visser   +12 more
doaj   +1 more source

Experimental Autoimmune Encephalomyelitis (EAE) as Animal Models of Multiple Sclerosis (MS).

Cold Spring Harbor Perspectives in Medicine, 2018
S. Glatigny, E. Bettelli
semanticscholar   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Male Factor Infertility and Risk of Multiple Sclerosis (MS): A Systematic Review and Meta-Analysis. [PDF]

J Family Reprod Health, 2023
Shahraki Z, Mohamadi A, Rastkar M, Ghajarzadeh M.   +3 more
europepmc   +1 more source

Design considerations for a multiple sclerosis fatigue mobile app MS Energize: A pragmatic iterative approach using usability testing and resonance checks

, 2021
Kirsten van Kessel, Duncan R. Babbage, Paula Kersten, Juliet Drown, Ann Sezier, Peter Thomas, Sarah Thomas   +6 more
openalex   +1 more source