Results 171 to 180 of about 6,883,088 (299)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

ProPIP: a tool for progressive multiple sequence alignment with Poisson Indel Process. [PDF]

BMC Bioinformatics, 2021
Maiolo M, Gatti L, Frei D, Leidi T, Gil M, Anisimova M.   +5 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Several multiple sequence alignment-perturbing methods enhance AlphaFold3 sampling of alternative protein states. [PDF]

Commun Chem
Eriksson Lidbrink S, Nissen I, Ahrlind JK, Howard RJ, Lindahl E.   +4 more
europepmc   +1 more source

PacRAT: a program to improve barcode-variant mapping from PacBio long reads using multiple sequence alignment. [PDF]

Bioinformatics, 2022
Yeh CC, Amorosi CJ, Showman S, Dunham MJ.   +3 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

BABAPPAlign: a multiple sequence alignment engine with a learned residue-level scoring function. [PDF]

Bioinformatics
Sinha K.
europepmc   +1 more source

Relative model selection of evolutionary substitution models can be sensitive to multiple sequence alignment uncertainty. [PDF]

BMC Ecol Evol, 2021
Spielman SJ, Miraglia ML.
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

A reinforcement learning-enhanced fuzzy multi-objective equilibrium optimization framework for multiple sequence alignment. [PDF]

Sci Rep
Hosseini H, Mansouri N, Mohammad Hasani Zade B.   +2 more
europepmc   +1 more source