We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui+5 more
wiley +1 more source
Sequence Flow: interactive web application for visualizing partial order alignments
Background Multiple sequence alignment (MSA) has proven extremely useful in computational biology, especially in inferring evolutionary relationships via phylogenetic analysis and providing insight into protein structure and function.
Krzysztof Zdąbłasz+2 more
doaj +1 more source
PacRAT: a program to improve barcode-variant mapping from PacBio long reads using multiple sequence alignment. [PDF]
Yeh CC+3 more
europepmc +1 more source
Improving performance of multiple sequence alignment analysis in multi-client environments [PDF]
Ümit V. Çatalyürek+4 more
openalex +1 more source
Introduction to Multiple Sequence Alignment
An introduction to multiple sequence alignments (MSAs) for bench biologists delivered as part of the EMBL Australia Masterclass on Protein Sequence Analysis http://oz-masterclass.wikispaces.com/ . Focuses on describing: the "anatomy" of a sequence alignment; two alternative interpretations of alignmetns (structural and evolutionary), and ways of ...
openaire +2 more sources
Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet+6 more
wiley +1 more source
Relative model selection of evolutionary substitution models can be sensitive to multiple sequence alignment uncertainty. [PDF]
Spielman SJ, Miraglia ML.
europepmc +1 more source
Multiple sequence alignment with arbitrary gap costs: Computing an optimal solution using polyhedral combinatorics [PDF]
Ernst Althaus+3 more
openalex +1 more source
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu+4 more
wiley +1 more source
Fast multiple alignment of ungapped DNA sequences using information theory and a relaxation method
Thomas D. Schneider+1 more
openalex +1 more source