Results 211 to 220 of about 756,544 (331)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Multiple sequence alignment of DNA-A sequences from ACMBFV, ACMV, CMMGV, EACMCV, EACMKV, EACMMV, EACMV, EACMZV, SACMV, ICMV, SLCMV (11 species)

, 2020
Alvin Crespo-Bellido, Siobain Duffy
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Large-scale structure-informed multiple sequence alignment of proteins with SIMSApiper. [PDF]

Bioinformatics
Crauwels C, Heidig SL, Díaz A, Vranken WF.   +3 more
europepmc   +1 more source

Automatic Discovery of Sub-molecular Sequence Domains in Multi-aligned Sequences: A Dynamic Programming Algorithm for Multiple Alignment Segmentation

, 2001
Eric Poe Xing, Denise M. Wolf, Inna Dubchak, Sylvia J. Spengler, Manfred Zorn, Ilya Muchnik, Casimir A. Kulikowski   +6 more
openalex   +2 more sources

ALIGNSEC: viewing protein secondary structure predictions within large multiple sequence alignments [PDF]

, 2017
Gilbert Deléage
openalex   +1 more source

msa: an R package for multiple sequence alignment

Bioinform., 2015
Ulrich Bodenhofer, Enrico Bonatesta, Christoph Horejs-Kainrath, Sepp Hochreiter   +3 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

One step forward towards deep-learning protein complex structure prediction by precise multiple sequence alignment construction. [PDF]

Clin Transl Med
Zheng W, Wuyun Q, Zhang Y.
europepmc   +1 more source

ABC: software for interactive browsing of genomic multiple sequence alignment data [PDF]

, 2004
Gregory M. Cooper, Senthil A. G. Singaravelu, Arend Sidow   +2 more
openalex   +1 more source