Results 221 to 230 of about 756,544 (331)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

PROMALS web server for accurate multiple protein sequence alignments [PDF]

, 2007
Jian Pei, Bo‐Hyun Kim, Miao Tang, Nick V. Grishin   +3 more
openalex   +1 more source

Using deep reinforcement learning approach for solving the multiple sequence alignment problem

SN Applied Sciences, 2019
Reza Jafari, M. Javidi, Marjan Kuchaki Rafsanjani   +2 more
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Curated multiple sequence alignment for the Adenomatous Polyposis Coli (APC) gene and accuracy of in silico pathogenicity predictions. [PDF]

PLoS One, 2020
Karabachev AD, Martini DJ, Hermel DJ, Solcz D, Richardson ME, Pesaran T, Sarkar IN, Greenblatt MS.   +7 more
europepmc   +1 more source

Multiple Sequence Alignment and Profile Analysis of Protein Family Utsing Hidden Markov Model

, 2012
Navjot Kaur, Rajbir Singh Cheema, Harmandeep Singh Harmandeep Singh, Harmandeep Singh Harmandeep Singh   +3 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Please Mind the Gap: Indel-Aware Parsimony for Fast and Accurate Ancestral Sequence Reconstruction and Multiple Sequence Alignment Including Long Indels. [PDF]

Mol Biol Evol
Iglhaut C, Pečerska J, Gil M, Anisimova M.   +3 more
europepmc   +1 more source

Inferring the genetic variability in Indian SARS-CoV-2 genomes using consensus of multiple sequence alignment techniques. [PDF]

Infect Genet Evol, 2020
Saha I, Ghosh N, Maity D, Sharma N, Mitra K.   +4 more
europepmc   +1 more source