Results 151 to 160 of about 1,270,686 (341)

Multiplicity and asymptotic behavior of solutions to fractional (p,q)-Kirchhoff type problems with critical Sobolev-Hardy exponent

Electronic Journal of Differential Equations, 2021
Xiaolu Lin, Shenzhou Zheng
doaj  

Variational approach to fractional boundary value problems with two control parameters

Electronic Journal of Differential Equations, 2015
This article concerns the multiplicity of solutions for a fractional differential equation with Dirichlet boundary conditions and two control parameters.
Massimiliano Ferrara, Armin Hadjian
doaj  

A Solution Procedure for the Design Problem of a Multiple Treatment Plant System along a Stream

, 1977
Demetrios Panagiotakopoulos
openalex   +2 more sources

Multiple solutions for a nonlinear elliptic equation on ${\bf R}^N$ with nonlinear dependence on the gradient [PDF]

, 1993
Chao-Nien Chen
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Exact solutions for anisotropic, multiple scattering by parallel plane dispersions [PDF]

, 1961
Stuart W. Churchill, Chiao-Min Chu, Lawrence B. Evans, Li-chiu. Tien, Sing-chin. Pang   +4 more
openalex  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Multiple positive solutions for singular multi-point boundary-value problem with general growth on the positive half line

Electronic Journal of Differential Equations, 2011
This work is devoted to the existence of nontrivial positive solutions for a class of second-order nonlinear multi-point boundary-value problems on the positive half-line. The novelty of this work is that the nonlinearity may exhibit a singularity at
Smail Djebali, Karima Mebarki
doaj  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source