Results 161 to 170 of about 1,270,686 (341)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Resonant (p,q)-equations with Robin boundary condition

Electronic Journal of Differential Equations, 2018
We consider a nonlinear nonhomogeneous Robin problem that has the sum of a p-Laplacian and a q-Laplacian (a (p,q)-equation). The reaction term is a Caratheodory function which is resonant at $\pm\infty$ with respect to any nonprincipal variational ...
Michael E. Filippakis, Nikolaos S. Papageorgiou   +1 more
doaj  

A Multiple Shooting Algorithm for Direct Solution of Optimal Control Problems *

, 1984
H.G. Bock, K.J. Plitt
openalex   +1 more source

Structure of the B‐Myb DNA‐binding Domain in Solution and Evidence for Multiple Conformations in the Region of Repeat‐2 Involved in DNA Binding [PDF]

, 1996
Mark D. Carr, Ute Wollborn, Pauline B. McIntosh, T.A. Frenkiel, John E. McCormick, Christopher J. Bauer, Karl‐Heinz Klempnauer, J. Feeney   +7 more
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Multiple solutions for a singular quasilinear elliptic system. [PDF]

ScientificWorldJournal, 2013
Chen L, Chen C, Xiu Z.
europepmc   +1 more source

Structure and multiple conformations of the Kunitz-type domain from human type VI collagen α3(VI) chain in solution [PDF]

, 1996
Markus Zweckstetter, Michael Czisch, Ulríke Mayer, Mon‐Li Chu, Wolfgang Zinth, Rupert Timpl, T.A. Holak   +6 more
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Strongly indefinite functionals with perturbed symmetries and multiple solutions of nonsymmetric elliptic systems

Electronic Journal of Differential Equations, 2004
We prove a critical-point result which provides conditions for the existence of infinitely many critical points of a strongly indefinite functional with perturbed symmetries.
Monica Clapp, Yanheng Ding, Sergio Hernandez-Linares   +2 more
doaj  

Existence of Multiple Solutions for a Quasilinear Biharmonic Equation. [PDF]

Int Sch Res Notices, 2014
Pan WW, Yu CE.
europepmc   +1 more source