Results 51 to 60 of about 1,270,686 (341)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Multiple solutions for a class of fractional equations
Electronic Journal of Qualitative Theory of Differential Equations, 2015 In this paper we study a class of fractional Laplace equations with asymptotically linear right-hand side. The existence results of three nontrivial solutions under the resonance and non-resonance conditions are established by using the minimax method ...
Ruichang Pei, Jihui Zhang, Caochuan Ma
doaj +1 more source
Nodal and constant sign solutions for singular elliptic problems [PDF]
arXiv, 2023 We establish the existence of multiple solutions for singular quasilinear elliptic problems with a precise sign information: two opposite constant sign solutions and a nodal solution. The approach combines sub-supersolutions method and Leray-Schauder topological degree involving perturbation argument.
arxiv
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Multiple solutions for nonresonance impulsive functional differential equations
Electronic Journal of Differential Equations, 2003 In this paper we investigate the existence of multiple solutions for first and second order impulsive functional differential equations with boundary conditions. Our main tool is the Leggett and Williams fixed point theorem.
Mouffak Benchohra, Abdelghani Ouahab
doaj
Multiple solutions of nonlinear boundary value problems with oscillatory solutions
Mathematical Modelling and Analysis, 2006 We consider two second order autonomous differential equations with critical points, which allow the detection of an exact number of solutions to the Dirichlet boundary value problem.
S. Ogorodnikova, F. Sadyrbaev
doaj +1 more source
Multiple solutions for a Schrödinger-Bopp-Podolsky system with positive potentials [PDF]
arXiv, 2020 In the paper we prove existence of solutions for a Schr\"odinger-Bopp-Podolsky system under positive potentials. We use the Ljusternick-Schnirelmann and Morse Theories to get multiple solutions with a priori given ``interaction energy''.
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Multiplicity results for the Neumann boundary value problem
Mathematical Modelling and Analysis, 2007 We provide multiplicity results for the Neumann boundary value problem, when the second order differential equation is of the form x” = f(x).
Svetlana Atslega
doaj +1 more source
Triangular Numbers Multiple of Triangular Numbers and Solutions of Pell Equations [PDF]
arXiv, 2021 For all positive non-square integer multiplier k, there is an infinity of multiples of triangular numbers which are also triangular numbers. With a simple change of variables, these triangular numbers can be found using solutions of Pell equations. With some conditions on parities of fundamental solutions of the simple and generalized Pell equations ...
arxiv