Results 81 to 90 of about 1,270,686 (341)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Electronic Journal of Differential Equations, 2013 This article presents global properties and existence of multiple solutions for a class of boundary value problems of impulsive differential equations.
Jing Wang, Baoqiang Yan
doaj
Real Solution Isolation with Multiplicity of Zero-Dimensional Triangular Systems [PDF]
arXiv, 2009 Existing algorithms for isolating real solutions of zero-dimensional polynomial systems do not compute the multiplicities of the solutions. In this paper, we define in a natural way the multiplicity of solutions of zero-dimensional triangular polynomial systems and prove that our definition is equivalent to the classical definition of local ...
arxiv
Three range measurements with multiplicative noises for single source localization problem [PDF]
arXiv, 2020 This purpose of this paper is to locate a single localized source from three range measurements with multiplicative noises. Although some minimization approaches for additive noise have been found, studies on the existence of solutions are rare. We analyzed a situation with one or two solutions for the same multiplicative noise at three measurement ...
arxiv
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
A solution of vehicle routing problems in a multiple objective environment [PDF]
, 1986 Yang Byung Park, C. Patrick Koelling
openalex +2 more sources
A more exact solution for incorporating multiplicative systematic uncertainties in branching ratio limits [PDF]
arXiv, 2006 A method to include multiplicative systematic uncertainties into branching ratio limits was proposed by M. Convery. That solution used approximations which are not necessarily valid. This note provides a solution without approximations and compares the results.
arxiv
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Steklov problems involving the p(x)-Laplacian
Electronic Journal of Differential Equations, 2014 Under suitable assumptions on the potential of the nonlinearity, we study the existence and multiplicity of solutions for a Steklov problem involving the p(x)-Laplacian. Our approach is based on variational methods.
Ghasem A. Afrouzi +2 more
doaj
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source