Results 151 to 160 of about 795,757 (316)

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Evolutionary States and Triplicity of Four Massive Semidetached Binaries with Long-term Decreasing Orbital Periods in the LMC

open access: yesThe Astrophysical Journal
The massive semidetached binary with a long-term decreasing orbital period may involve a rapid mass-transfer phase in Case A, and thus, they are good astrophysical laboratories for investigating the evolution of massive binary stars.
Fu-Xing Li   +8 more
doaj   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

open access: yesMolecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian   +12 more
wiley   +1 more source

Toward Early-type Eclipsing Binaries as Extragalactic Milestones. III. Physical Properties of the O-type Eclipsing Binary OGLE LMC-ECL-21568 in a Quadruple System ,

open access: yesThe Astrophysical Journal
We present the results from a complex study of an eclipsing O-type binary (Aa+Ab) with the orbital period of  P _A = 3.2254367 days that forms part of a higher-order multiple system in a configuration of (A+B)+C. We derived masses of the Aa+Ab binary of 
Mónica Taormina   +10 more
doaj   +1 more source

Commission 26: Double and Multiple Stars [PDF]

open access: bronze, 2005
William I. Hartkopf   +8 more
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

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