Predictive value of red blood cell distribution width in critically ill patients with acute respiratory distress syndrome: A meta-analysis. [PDF]
Hou FF+7 more
europepmc +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source
Revitalizing Astronomical Azimuth Determination: Integrating Modern Computing with Traditional Techniques. [PDF]
Barazzetti L.
europepmc +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias+12 more
wiley +1 more source
Encoding Genes of Metallo β-Lactamases (<i>IMP</i>, <i>NDM</i>, and <i>VIM</i>) in <i>Klebsiella Pneumoniae</i> in Iran: A Systematic Review and Meta-Analysis. [PDF]
Sadeghi H+8 more
europepmc +1 more source
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach+8 more
wiley +1 more source
Black Holes as Laboratories: Tests of General Relativity. [PDF]
Gregory R, Nissanke S.
europepmc +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche+8 more
wiley +1 more source
The dynamics of leadership and success in software development teams. [PDF]
Betti L, Gallo L, Wachs J, Battiston F.
europepmc +1 more source