Results 231 to 240 of about 5,074,994 (301)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

EnzymeSifter: a tool for discovery of industrial enzymes from metagenomes. [PDF]

Bioinform Adv
Darawsheh O, Bashton M.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A new paradigm for esophageal disease management: the application and future prospects of Shared Decision Making (SDM). [PDF]

World J Surg Oncol
Yin Y, Zhang J, Yang M, Zhao C, Li K, Shen C.   +5 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Comparison of liver T1 estimates generated by breath-hold 3D FSPGR and free-breathing 3D radial stack-of-stars FSPGR variable flip angle T1 mapping sequences. [PDF]

Eur J Radiol Open
Xu H, Hou Z, Zhang M, Guo R, Zhang J, Fu G, Wen Q, Li Z, Tao F, Yang S.   +9 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Discovery of a star sensitive to the spin of Sagittarius A. [PDF]

Nature
Abd El Dayem K, Abuter R, Aimar N, Amaro-Seoane P, Berdeu A, Berger JP, Bourdarot G, Brandner W, Burkert A, Caldéron D, Correia C, Cuadra J, Davies R, Defrère D, Delit L, Drescher A, Eisenhauer F, Esteras Otal L, Fabricius M, Feuchtgruber H, Flesch S, Förster Schreiber NM, Foschi A, Fournier Q, Garcia P, Garcia Lopez R, Generozov A, Genzel R, Gillessen S, Gonté F, Haubois X, Hönig SF, Houllé M, Joharle S, Kaufer A, Kammerer J, Kervella P, Kolb J, Kreidberg L, Labadie L, Lacour S, Lai O, Laugier R, Le Bouquin JB, Leftley J, Li R, Lopez B, Lutz D, Mang F, Mérand A, Millour F, Montargès M, Morujão N, Nowacki H, Nowak M, Oberti S, Osorno J, Ott T, Paumard T, Paladini C, Pappert S, Perets HB, Perraut K, Perrin G, Petrov R, Petrucci PO, Piran T, Pourré N, Rabien S, Ribeiro DC, Robbe-Dubois S, Sadun Bordoni M, Sanchez-Bermudez J, Santos D, Sari R, Sauter J, Scheithauer S, Scigliuto J, Shangguan J, Shimizu TT, Soulez F, Stadler J, Straubmeier C, Sturm E, Subroweit M, Sykes C, Tacconi LJ, Thévenet P, Urso I, Vincent F, Woillez J, Zins G, GRAVITY+ Collaboration.   +92 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Development of a mobile application tracking stats and goals of young basketball players: design-based research. [PDF]

Front Psychol
Tascioglu R, Turgut C, Usta I, Kocaeksi S.   +3 more
europepmc   +1 more source