Results 271 to 280 of about 508,501 (339)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Systematic review of the prevalence of environmental and host-related risk factors and the zoonotic potential of leptospirosis in domestic dogs in regions impacted by environmental changes. [PDF]

BMC Vet Res
Heydari P, Tirbandpay M, Ghasemishayan R.   +2 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Bogong moths use a stellar compass for long-distance navigation at night. [PDF]

Nature
Dreyer D, Adden A, Chen H, Frost B, Mouritsen H, Xu J, Green K, Whitehouse M, Chahl J, Wallace J, Hu G, Foster J, Heinze S, Warrant E.   +13 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Radiomics-Based Artificial Intelligence and Machine Learning Approach for the Diagnosis and Prognosis of Idiopathic Pulmonary Fibrosis: A Systematic Review. [PDF]

Cureus
Khalid A, Mushtaq MM, Sattar S, Soe YN, Ismail S, Haris M, Ullah S, Hassan MW, Bhatti MM, Ali H.   +9 more
europepmc   +1 more source

The GALAH survey: Multiple stars and our Galaxy. I. A comprehensive method for deriving properties of FGK binary stars

, 2020
G. Traven, S. Feltzing, T. Merle, M. Van der Swaelmen, Klemen Čotar, Ross P. Church, T. Zwitter, Yuan-Sen Ting, C. Sahlholdt, M. Asplund, Joss Bland‐Hawthorn, G. De Silva, K. C. Freeman, Sarah L. Martell, Sanjib Sharma, D. B. Zucker, Sven Buder, Andrew R. Casey, V. D’Orazi, Janez Kos, Geraint F. Lewis, J. Lin, K. Lind, Jeffrey D. Simpson, Dennis Stello, U. Munari, Robert A. Wittenmyer   +26 more
openalex  

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Decoding non-human mammalian adaptive signatures of 2.3.4.4b H5N1 to assess its human adaptive potential. [PDF]

Microbiol Spectr
Nataraj R, Ashok AK, Dey AA, Kesavardhana S.   +3 more
europepmc   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source