Results 131 to 140 of about 482,148 (298)

Choosing alpha post hoc:the danger of multiple standard significance thresholds [PDF]

A fundamental assumption of classical hypothesis testing is that the significance threshold α is chosen independently from the data. The validity of confidence intervals likewise relies on choosing α beforehand. We point out that the independence of α is
Hemerik, Jesse; id_orcid, Koning, Nick
core   +2 more sources

Multiple Dimensions Define Thresholds for Population Resilience of the Eastern Oyster, Crassostrea virginica

Ecology and Evolution
A species' distribution depends on its tolerance to environmental conditions. These conditions are defined by a minimum, maximum, and optimal ranges of single and combined factors.
Megan K. La Peyre, Hongqing Wang, Shaye E. Sable, Wei Wu, Bin Li, Devin Comba, Carlos Perez, Melanie Bates, Lauren M. Swam   +8 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

NETWORK META-ANALYSIS OF DIAGNOSTIC TEST ACCURACY STUDIES ALLOWING FOR MULTIPLE TESTS AT MULTIPLE THRESHOLDS FOR HEALTHCARE POLICY AND DECISION MAKING

, 2018
Objectives Network meta-analyses have extensively been used to compare the effectiveness of multiple interventions for healthcare policy and decision-making. Methods for evaluating the performance of multiple diagnostic tests are less established.
NJ Cooper (7657223), T Quinn (7734434), R Owen (3216162), A Sutton (7734437)   +3 more
core   +1 more source

Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior

Communications Biology
Genome-wide association studies (GWAS) identify genetic variants underlying complex traits but are limited by stringent genome-wide significance thresholds. We present GRIN (Gene set Refinement through Interacting Networks), which increases confidence in
Kyle A. Sullivan, Matthew Lane, Mikaela Cashman, J. Izaak Miller, Mirko Pavicic, Angelica M. Walker, Ashley Cliff, Jonathon Romero, Xuejun Qin, Niamh Mullins, Anna Docherty, Hilary Coon, Douglas M. Ruderfer, International Suicide Genetics Consortium, VA Million Veteran Program, MVP Suicide Exemplar Workgroup, Michael R. Garvin, John P. Pestian, Allison E. Ashley-Koch, Jean C. Beckham, Benjamin McMahon, David W. Oslin, Nathan A. Kimbrel, Daniel A. Jacobson, David Kainer   +24 more
doaj   +1 more source

Advances in thresholding and multiple comparisons

, 2017
Talk given at the 2014 Organization for Human Brain Mapping (OHBM) conference in Hamburg, 8-12 June.
openaire   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Trajectories and thresholds of multitrophic diversities and multiple functions in response to nitrogen enrichment

Communications Biology
Global nitrogen deposition has profound impacts on ecosystem biodiversity and functions. However, the response trajectories and thresholds of the diversities of multiple trophic groups and multiple functions to nitrogen enrichment remain unclear.
Yang Yang, Yang Li, Yaxiang Lü, Liangchao Jiang, Guojiao Yang, Binger An, Wei Liu, Jiamei Sun, Jing Wang, Zhengwen Wang, Xingguo Han, Qingmin Pan   +11 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Contour Detection Thresholds.

, 2013
Mean contour detection thresholds are plotted for 28 healthy controls (circles), 13 first-degree relatives (squares), and 25 patients with schizophrenia (triangles) for the Parallel (red), Random (gray), and Orthogonal (blue) conditions. Example contours
Scott R. Sponheim (159672), Michael-Paul Schallmo (423157), Cheryl A. Olman (176715)   +2 more
core   +1 more source