Results 111 to 120 of about 482,148 (298)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Capsaicin (8%) patch increases multiple electrical nociceptive thresholds in healthy human subjects [PDF]

, 2013
Thresholds are dependent on stimulus properties and are related to different mechanisms in the nociceptive system. Measuring multiple thresholds enables a detailed observation of peripheral and central nociceptive processing.
Veltink, P.H., van Amerongen, G., Buitenweg, Jan R.; id_orcid, Doll, Robert, Hay, J.L., Groeneveld, G.J., Buitenweg, Jan R.   +6 more
core  

Absolute height-specific thresholds to identify elevated blood pressure in children

, 2013
Identification of children with elevated blood pressure (BP) is difficult because of the multiple sex, age, and height-specific thresholds to define elevated BP.
Paradis, Gilles, Simonetti, Giacomo D, Bovet, Pascal, Chiolero, Arnaud   +3 more
core   +1 more source

Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

, 2019
Objective: To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis.
Elena H. Martínez‐Lapiscina, Behbehani, Raed, Lisanne Balk, Galetta, Steven L., Pablo Villoslada, Papadopoulou, Athina, Leocani, L., Shiv Saidha, Hong Jiang, Teresa Frohman, Nolan-Kenney, Rachel C., Pisa, Marco, Benjamin Knier, Paul, Friedemann, Omar Akhand, Petzold, A., Saidha, S., Steven L. Galetta, Jiang, H., Mengling Liu, Laura J. Balcer, Raed Behbehani, Al-Hassan, Abdullah Abu, Petzold, Axel, Rachel C. Nolan‐Kenney, Martínez-Lapiscina, Elena H., Calabresi, P.A., Abu Al-Hassan, A., Akhand, O., Havla, J., Friedemann Paul, Galetta, Steven L, Martínez-Lapiscina, E.H., Villoslada, P., Brandt, Alexander U., Frohman, E.M., Hemmer, Bernhard, Galetta, S.L., Peter A. Calabresi, Axel Petzold, Akhand, Omar, Calabresi, Peter A., Balcer, L.J., Paul, F., Calabresi, Peter A, Behbehani, R., Korn, Thomas, Saidha, Shiv, Hemmer, B., Balcer, Laura J, Liu, Mengling, Frohman, Teresa, Frohman, T., Martínez-Lapiscina, Elena H, Nolan, R.C., Brandt, Alexander U, Bernhard Hemmer, Joachim Havla, Nolan-Kenney, Rachel C, Athina Papadopoulou, Knier, Benjamin, Havla, Joachim, Knier, B., Abdullah Abu Al‐Hassan, Zimmermann, Hanna, Liu, M., Jiang, Hong, Pisa, M., Balcer, Laura J., Zimmermann, H., Alexander U. Brandt, Frohman, Elliot M., Hanna Zimmermann, Papadopoulou, A., Thomas Korn, Villoslada, Pablo, Korn, T., Leocani, Letizia, Balk, L., Brandt, A.U., Marco Pisa, Balk, Lisanne, Letizia Leocani, Elliot M. Frohman, Frohman, Elliot M   +84 more
core   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

DEVELOPING FLEXIBLE ECONOMIC THRESHOLDS FOR PEST MANAGEMENT USING DYNAMIC PROGRAMMING

The rice stink bug is a major pest of rice in Texas, causing quality related damage. The previous threshold used for assisting in rice stink bug spray decisions lacked flexibility in economic and production decision variables and neglected the dynamics ...
Harper, Jayson K., Rister, M. Edward, Way, Michael O., Drees, Bastiaan M., Mjelde, James W.   +4 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Boosting multiple experts by joint optimisation of decision thresholds

, 2001
We consider a multiple classifier system which combines the hard decisions of experts by voting. We argue that the individual experts should not set their own decision thresholds.
Christmas, W, Kittler, J, Windeatt, T, Windridge, D, Yusoff, Y   +4 more
core  

Comparison of Centor and McIsaac scores in primary care: a meta-analysis over multiple thresholds. [PDF]

Br J Gen Pract, 2020
Willis BH, Coomar D, Baragilly M.
europepmc   +1 more source