Results 91 to 100 of about 482,148 (298)

On general frameworks and threshold functions for multiple domination

open access: yesDiscrete Mathematics, 2015
We consider two general frameworks for multiple domination, which are called -domination and parametric domination. They generalise and unify {k}-domination, k-domination, total k-domination and k-tuple domination. In this paper, known upper bounds for the classical domination are generalised for the -domination and parametric domination numbers. These
openaire   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Environmental Policy and the Macroeconomy in the Presence of Ecological Thresholds [PDF]

open access: yes
We study the environmental and economic effects of public abatement in the presence of multiple stable steady-state ecological equilibria. Under shallow-lake dynamics (SLD), the isocline for the stock of pollution features two stable branches, a good and
Heijdra, Ben J., Heijnen, Pim
core  

Effect of physical exercise on pain thresholds and plasma beta-endorphins in patients with silent and symptomatic myocardial ischaemia

open access: yes, 1988
In a double-blind study, eight patients with symptomatic myocardial ischaemia and nine with asymptomatic myocardial ischaemia were compared during physical exercise under naloxone (6 mg i.v.) or placebo. Plasma beta-endorphin, cortisol and catecholamines
Roskamm, H.   +3 more
core   +1 more source

Multiple thermal Atlantic Meridional Overturning Circulation thresholds in the intermediate complexity model Bern3D [PDF]

open access: yesClimate of the Past
Variations in the Atlantic Meridional Overturning Circulation (AMOC) are associated with Northern Hemispheric and global climate shifts. Thermal thresholds of the AMOC have been found in a hierarchy of numerical circulation models, and there is an ...
M. Adloff   +9 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Multiple-burst-error correction by threshold decoding

open access: yesInformation and Control, 1969
A class of cyclic product codes capable of correcting multiple-burst errors is studied. A code of dimension \(p\) is constructed by forming the cyclic product of \(p\) one-dimensional single-parity-check codes of relatively prime block lengths. A consideration of the parity-check matrix shows that there are \(p\) orthogonal parity checks on each digit,
Lalit R. Bahl, Robert T. Chien
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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