Results 101 to 110 of about 482,148 (298)
Latent Thresholds Analysis of Choice Data with Multiple Bids and Response Options [PDF]
In many stated preference settings stakeholders will be uncertain as to their exact willingness-to-pay for a proposed environmental amenity. To accommodate this possibility analysts have designed elicitation formats with multiple bids and response ...
Klaus Moeltner +2 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The Simple Economics of Thresholds: Evidence from the Western States 100 [PDF]
Many public and private entities utilize incentive systems in which improvements in measured performance are rewarded only if the agent crosses some pre-specified threshold.
Darren Grant
core
Finite Percolation at a Multiple of the Threshold
, 2006 Bond percolation on infinite heavy-tailed power-law random networks lacks a proper phase transition; or one may say, there is a phase transition at {\em zero percolation probability}. Nevertheless, a finite size percolation threshold $q_c(N)$, where $N$ is the network size, can be defined.
Sarshar, Nima +2 more
openaire +2 more sources
Floer cohomology, multiplicity and the log canonical threshold [PDF]
Geometry & Topology, 2019 Let f be a polynomial over the complex numbers with an isolated singularity at 0. We show that the multiplicity and the log canonical threshold of f at 0 are invariants of the link of f viewed as a contact submanifold of the sphere. This is done by first constructing a spectral sequence converging to the fixed point Floer cohomology of any iterate of ...
openaire +4 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
BMC Medical EducationBackground MCQ exams may include flawed items affecting validity. Psychometric indicators such as item difficulty (p-value) and point-biserial coefficient (rpb-value) are widely used to identify problematic questions. Evidence on using p-value (
Varanya Srisomsak +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source