Results 51 to 60 of about 482,148 (298)

Objective frequency-specific hearing thresholds definition for medicolegal purposes in case of occupational NIHL: ASSR outperforms CERA

Journal of Otology, 2021
Audiological use of the 40 Hz-ASSR (auditory steady state responses) could be valuable for objectively estimating the frequency-specific threshold in adults undergoing an expertise examination for medicolegal and/or compensation purposes.
P.H. DeJonckere, B. Millet, R. Van Gool, A. Martens, J. Lebacq   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Generating High-Order Threshold Functions with Multiple Thresholds

CoRR, 2012
In this paper, we consider situations in which a given logical function is realized by a multithreshold threshold function. In such situations, constant functions can be easily obtained from multithreshold threshold functions, and therefore, we can show that it becomes possible to optimize a class of high-order neural networks.
Yukihiro Kamada, Kiyonori Miyasaki
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Channel Modeling and Quantization Design for 3D NAND Flash Memory

Entropy, 2023
As the technology scales down, two-dimensional (2D) NAND flash memory has reached its bottleneck. Three-dimensional (3D) NAND flash memory was proposed to further increase the storage capacity by vertically stacking multiple layers.
Cheng Wang, Zhen Mei, Jun Li, Feng Shu, Xuan He, Lingjun Kong   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Not all roads lead to the immune system: the genetic basis of multiple sclerosis severity [PDF]

, 2022
Multiple sclerosis is a leading cause of neurological disability in adults. Heterogeneity in multiple sclerosis clinical presentation has posed a major challenge for identifying genetic variants associated with disease outcomes.
Kleinova, Pavlina, Laverick, Louise, Kubala Havrdova, Eva, Campagna, Maria Pia, Ibrahim, Omar, Matesanz, Fuencisla, Lechner-Scott, Jeannette, Garcia-Sanchez, Maria-Isabel, Taylor, Bruce, Eichau, Sara, Patsopoulos, Nikolaos, Slee, Mark, Izquierdo, Guillermo, Kalincik, Tomas, Havrdova, Eva Kubala, Alcina, Antonio, van der Walt, Anneke, Vodehnalova, Karolina, Vucic, Steve, De Jager, Philip L., Lea, Rodney, García-Sánchez, María Isabel, Taylor, Bruce V., Hui, Daniel, Kilpatrick, Trevor J., Beecham, Ashley, Jokubaitis, Vilija G., McCauley, Jacob L., Horakova, Dana, Butzkueven, Helmut, Ibrahim, Omar A., Stankovich, Jim   +31 more
core   +1 more source

Short report: Establishing normal hearing for infants with the auditory steady-state response

South African Journal of Communication Disorders, 2005
This study investigated the use of the dichotic multiple frequency ASSR technique for characterising normal hearing in a group of infants. A descriptive research design was implemented to describe ASSR thresholds obtained in 10 normal hearing infant ears
De Wet Swanepoel, Karen Steyn
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source