Results 111 to 120 of about 8,012,310 (396)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

An invitation to grieve: reconsidering critical incident responses by support teams in the school setting [PDF]

, 1991
This paper proposes that consideration could be given to an invitational intervention rather than an expectational intervention when support personnel respond to a critical incident in schools.
A Kahn, A Kahn, A Kahn, A Kahn, A Wacholder, B Lozoff, B Spilker, B Taubman, B Zuckerman, C Guillemniault, C Guillemniault, C Zanussi, DA Moneret-Vautrin, EH Wender, HI Leeks, J Eaton-Evans, J Egger, JF Bernal, JP Harley, M Weissbluth, M Wesissbluth, MA Keener, MCO Bax, MF Elias, N Blurton-Jones, N Richman, N Richman, R Ferber, S Jenkins, SL Bahna, T Moore, TF Anders, WB Carey   +32 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Traumatismos de páncreas: diagnóstico y tratamiento Pancreatic trauma: diagnosis and treatment

Revista Colombiana de Cirugía, 2008
Los traumatismos de páncreas son infrecuentes; representan, aproximadamente, el 4% de las lesiones abdominales pero conllevan una tasa de morbimortalidad significativa, razón por la cual es primordial su reconocimiento y tratamiento precoz.
Patrizio Petrone, Juan A Asensio, Marcela Pardo, Brian Kimbrell, Eric Kuncir   +4 more
doaj  

Determination of Clinical Signs and Symptoms Predicting No Pelvic Fracture in Patients with Multiple Trauma

Advanced Biomedical Research, 2018
Background: Pelvic fracture (PF) is the second-most prevalent cause of mortality after brain trauma among multiple trauma patients. Our aim was to examine the reliability of suggestive criteria for having no PF (NPF) according to the common reported ...
Saeed Majidinejad, Farhad Heidari, Hosein Kafi Kang, Keyhan Golshani   +3 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Transitions of patients with traumatic brain injury and multiple trauma between specialized and municipal rehabilitation services—Professionals’ perspectives

Cogent Medicine, 2017
Rehabilitation is a complex field requiring broad interprofessional and interorganizational collaboration. System-induced setbacks, such as rehospitalization and decreased quality of care, can occur when patients transition between services. The focus of
Mirela Slomic, Helene L. Soberg, Unni Sveen, Bjørg Christiansen   +3 more
doaj   +1 more source

Disrupting the Path from Childhood Trauma to Juvenile Justice: An Upstream Health and Justice Approach [PDF]

, 2016
A groundbreaking public health study funded by the U.S. Centers for Disease Control and Prevention (CDC) and the Kaiser Foundation found astoundingly high rates of childhood trauma, including experiences like abuse, neglect, parental substance abuse ...
Cannon, Yael, Hsi, Andrew
core   +2 more sources

Shock volume: Patient-specific cumulative hypoperfusion predicts organ dysfunction in a prospective cohort of multiply injured patients [PDF]

, 2018
BACKGROUND: Multiply injured patients are at risk of developing hemorrhagic shock and organ dysfunction. We determined how cumulative hypoperfusion predicted organ dysfunction by integrating serial Shock Index measurements. METHODS: In this study,
Bell, Teresa M., Gaski, Greg E., McCarroll, Tyler, McKinley, Todd O., Metzger, Cameron, Savage, Stephanie A., Zarzaur, Ben L.   +6 more
core   +2 more sources