Results 91 to 100 of about 8,012,310 (396)

Multiple Casualty Incidents at a Level I Trauma Center: A 15-year Analysis [PDF]

, 2023
Cynthia J. Susai, Nathan J. Alcasid, Kian C. Banks, Gregory P. Victorino   +3 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Acquired Factor XIII Deficiency in Patients with Multiple Trauma [PDF]

, 2022
Michael Hetz, Tareq A. Juratli, Oliver Tiebel, M. Giesecke, Serafeim Tsitsilonis, Hanns-Christoph Held, Franziska Beyer, Christian Kleber   +7 more
openalex   +1 more source

The Antimicrobial Peptide Lysozyme Is Induced after Multiple Trauma

Mediators of Inflammation, 2014
The antimicrobial peptide lysozyme is an important factor of innate immunity and exerts high potential of antibacterial activity. In the present study we evaluated the lysozyme expression in serum of multiple injured patients and subsequently analyzed ...
T. Klüter, S. Fitschen-Oestern, S. Lippross, M. Weuster, R. Mentlein, N. Steubesand, C. Neunaber, F. Hildebrand, T. Pufe, M. Tohidnezhad, A. Beyer, A. Seekamp, D. Varoga   +12 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Recognizing, Treating, and Preventing Trauma in LGBTQ Youth [PDF]

, 2017
Extensive research has demonstrated that lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) youth are disproportionally affected by a variety of traumatic experiences including verbal, physical, and sexual abuse.
Mooney, Megan
core   +1 more source

Recurrent violent injury: magnitude, risk factors, and opportunities for intervention from a statewide analysis. [PDF]

, 2016
INTRODUCTION: Although preventing recurrent violent injury is an important component of a public health approach to interpersonal violence and a common focus of violence intervention programs, the true incidence of recurrent violent injury is unknown ...
Crandall, Marie L., Delgado, M. Kit, Ebler, David J., Kaufman, Elinore, Rising, MD, MS, Kristin L., Wiebe, Douglas J.   +5 more
core   +2 more sources

Utility of bispectral index in the management of multiple trauma patients

Surgical neurology international, 2014
Background: Bispectral index (BIS) monitoring in multiple trauma patients has become a common practice in monitoring the sedation levels. We aimed to assess the utility of BIS in the trauma intensive care unit (ICU).
S. Mahmood, A. Parchani, A. El-Menyar, A. Zarour, H. Al-Thani, R. Latifi   +5 more
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source