Results 71 to 80 of about 5,528,146 (299)

The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. [PDF]

, 2013
BACKGROUND Among trauma patients who survive to reach hospital, exsanguination is a common cause of death. A widely practicable treatment that reduces blood loss after trauma could prevent thousands of premature deaths each year.
Ramos, M., Coats, T., T Coats, M Ramos, Perel, P, T Kawahara, Cook, L, Roberts, I., Kawahara, T, Hunt, B, C Guerriero, B Hunt, Barnetson, L, Ramos, M, Kawahara, T., Cook, L., Guerriero, C, I Roberts, E Balogun, Cairns, J, Barnetson, L., Cairns, J., Balogun, E, Prieto-Merino, D, Perel, P., Hunt, B., Coats, T, Balogun, E., L Cook, P Perel, Prieto-Merino, D., H Shakur, D Prieto-Merino, Guerriero, C., J Cairns, Shakur, H, Shakur, H., Roberts, I, L Barnetson   +38 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Characteristics of Mortalities related to Pulmonary Embolism following Multiple Trauma; a Brief Report

Emergency, 2018
Introduction: Pulmonary embolism (PE) is introduced as the third major cause of death after trauma in those who survive more than 24 hours. This study aimed to describe the characteristics of mortalities due to trauma related PE in cases referred to the ...
Fares Najari, Babak Mostafazadeh, Asadollah Akbari, Ideh Baradaran kaya, Dorsa Najari   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The effect of body mass index on trauma severity and prognosis in trauma patients

, 2016
BACKGROUND: As in the rest of the world, the prevalence of obesity in Turkey has been increasing in recent years and has become a major public health issue.
Ustundag, Mehmet, Dursun, Recep, Zengin, Yilmaz, Orak, Murat, Ozhasenekler, Ayhan, Durgun, Hasan Mansur, Guloglu, Cahfer   +6 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Does early or late motion after nerve repair alter the results in combined forearm injuries

Acta Orthopaedica et Traumatologica Turcica, 2021
Objectives: To determine whether there are differences in terms of nerve repair between two different methods of rehabilitation after primary repair of combined injuries in the forearm, namely early controlled motion and immobilization for three weeks ...
Tunc Cevat Ogun, Mehmet Arazi
doaj  

Trauma-informed services and trauma-specific care for Indigenous Australian children [PDF]

, 2013
This paper examines how childhood trauma experienced by Indigenous children can be overcome by appropriate interventions.IntroductionWhile many Indigenous and non-Indigenous Australian children grow up in safe homes and live in safe communities, there ...
Judy Atkinson
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source