Results 71 to 80 of about 451,158 (311)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Frequency, causes, and outcomes of trauma in patients referred to the emergency department of Ali Ibn Abitaleb hospital, Rafsanjan, Iran, in 2021 [PDF]

Archives of Trauma Research
Background: Trauma is a leading cause of morbidity and mortality worldwide. The frequency of trauma-related deaths depends on various factors such as the severity and mechanism of the trauma.Objectives: This study aimed to determine the frequency, causes,
Elham Ganjurzadeh, Zahra Kamiab, Seyed Reza Hosseiniara, Solmaz Sadat Hosseini Zijoud, Afsaneh Esmaeili Ranjbar   +4 more
doaj   +1 more source

Awareness of Dealing with Multiple Trauma Patients in Madinah, Saudi Arabia [PDF]

, 2018
Moayad A. Karbouji, Yousef Alrashidi, Mohanad I. Kashkari, Mujahed A. Turjoman, Sultan F. Madani, Fahad A. Almukhlifi   +5 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Percepção dos profissionais de enfermagem frente à identificação, quantificação e tratamento da dor em pacientes de uma unidade de terapia intensiva de trauma

Revista Dor
JUSTIFICATIVA E OBJETIVOS: O trauma tem importância no âmbito mundial por ser uma das principais causas de morte e invalidez. A dor aguda sempre acompanha os pacientes vítimas de trauma e os profissionais da saúde têm dificuldade em identificá-la e ...
Paola Alexandria Pinto Magalhães, Fabiane Almeida Mota, Carmen Mohamad Rida Saleh, Lígia Maria Dal Secco, Solange Regina Giglioli Fusco, Áquila Lopes Gouvêa   +5 more
doaj   +1 more source

CLOTTING DISORDERS IN MULTIPLE TRAUMA

Вестник анестезиологии и реаниматологии, 2018
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R. M. Gabdulkhakov, R. F. Rakhimova, I. I. Lutfarakhmanov, G. A. Biktimirova, B. V. Vakeev   +4 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source