Results 191 to 200 of about 238,223 (293)

Healthy Participant Versus Patient Selection for Clinical Pharmacology Studies in Small-Molecule Oncology Drug Development. [PDF]

Clin Transl Sci
Gupta P, Hu Z, Zhu L, Hamuro L.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Variations in the Timing of Bipolar Mood Cycles Associated With Interactions of the Moon's Synodic, Tropical, and Anomalistic Cycles. [PDF]

J Biol Rhythms
Wehr TA, Avery DH.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Enantiomer-dependent biodistribution and exposure determine the <i>in vivo</i> behavior of a pleurocidin-derived antimicrobial peptide. [PDF]

mBio
Romanopulos J, Cressey P, Hind CK, Kim S-H, Shalim ZA, Mohamed Akram N, Alnasif Alhadi H, Claxton A, You Y, Kelis AV, Ramsden B, Memdouh S, Jacob AC, Bui TT, Cleary SJ, Thanou M, Amison RT, Abbate V, Sutton JM, Mason AJ.   +19 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Attenuation of surface-related multiples for single-channel seismic survey in offshore engineering. [PDF]

Sci Rep
Shen H, Che H, Chen F, Wang B, Liu S, Zhang C, Wang C, Zhao J.   +7 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Multiples et multiplications dans Peter Pan

Belphégor, 2011
Monique Chassagnol
doaj   +1 more source

Author Correction: Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation. [PDF]

NPJ Vaccines
Sherry L, Grehan K, Bahar MW, Swanson JJ, Fox H, Matthews S, Carlyle S, Qin L, Porta C, Wilkinson S, Robb S, Clark N, Liddell J, Fry EE, Stuart DI, Macadam AJ, Rowlands DJ, Stonehouse NJ.   +17 more
europepmc   +1 more source