Results 91 to 100 of about 281,955 (321)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
Observability transition in multiplex networks [PDF]
, 2017 We extend the observability model to multiplex networks. We present mathematical frameworks, valid under the treelike ansatz, able to describe the emergence of the macroscopic cluster of mutually observable nodes in both synthetic and real-world multiplex networks.
arxiv +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
FEBS Open Bio, EarlyView.Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy +14 more
wiley +1 more source
Biomarker Insights, 2008 Serum parameters as indicators for the efficacy of therapeutic drugs are currently in the focus of intensive research. The induction of certain cytokines (or cytokine patterns) is known to be related to the status of the immune response e.g.
Ivan M. Roitt +3 more
doaj
A Novel Compressive Sensing based Enhanced Multiplexing Scheme for MIMO System [PDF]
arXiv, 2016 A novel compressive-sensing based signal multiplexing scheme is proposed in this paper to further improve the multiplexing gain for multiple input multiple output (MIMO) system. At the transmitter side, a Gaussian random measurement matrix in compressive sensing is employed before the traditional spatial multiplexing in order to carry more data streams
arxiv
FEBS Open Bio, EarlyView.We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui +5 more
wiley +1 more source
A novel space division multiplexing system for free space optical communications [PDF]
arXiv, 2013 We propose a novel space division multiplexing (SDM) technique based on spatial phase encoding, which may provide a new perspective beyond the conventional SDM in free space optical communications, such as multiplexing of orbital angular momentum (OAM).
arxiv
Meta-analysis highlight the therapeutic potential of stem cells for premature ovarian failure
Regenerative TherapyStem cell (SC) transplantation has shown potential as a therapeutic approach for premature ovarian failure (POF). Despite this, no quantitative analysis has been conducted on the efficacy of SC therapy for POF in humans.
Amna Umer +5 more
doaj