Results 221 to 230 of about 31,893 (252)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

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Multiplex Networks

SpringerBriefs in Complexity, 2018
Francisco A. Rodrigues, Yamir Moreno, Emanuele Cozzo   +2 more
exaly   +2 more sources

Statistical multiplexing in ATM networks

Performance Evaluation, 1991
Abstract In this paper we evaluate the statistical multiplexing gain in ATM networks for bursty as well as variable bit rate (VBR) traffic using a fluid-flow approximate model. We obtain the required bandwidth per source in a finite buffer multiplexer in order to achieve a given Grade of Service (GOS), expressed by the cell loss probability. For both
José Augusto Suruagy Monteiro, Mario Gerla, Luigi Fratta   +2 more
openaire   +1 more source

Multiplex networks

Proceedings of the 2015 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining 2015, 2015
Real-world networks often consist of multiple layers, be they infrastructure such as airline networks or social such as collaboration networks. A common aspect to these networks is that there are multiple sub-networks that evolve in parallel on the same node set -- these are referred to as multiplex networks.
Prithwish Basu, Ravi Sundaram, Matthew Dippel   +2 more
openaire   +2 more sources

Line graphs for a multiplex network

Chaos: An Interdisciplinary Journal of Nonlinear Science, 2016
It is well known that line graphs offer a good summary of the graphs properties, which make them easier to analyze and highlight the desired properties. We extend the concept of line graph to multiplex networks in order to analyze multi-plexed and multi-layered networked systems.
Regino Criado, Julio Flores, Alejandro García del Amo, Miguel Romance, Eva Barrena, Juan A. Mesa   +5 more
openaire   +2 more sources

TYMNET as a multiplexed packet network

Proceedings of the June 13-16, 1977, national computer conference on - AFIPS '77, 1977
TYMNET is a commercially successful computer network that has been in continuous operation since November, 1971. It contains over 200 nodes. Circuit routing is established by a central process, the supervisor.TYMNET has never been fully documented in the literature.
openaire   +2 more sources

Cell multiplexing in ATM networks

IEEE/ACM Transactions on Networking, 1996
Formulates, analyzes, and compares several connection multiplexing algorithms for a multiplexer residing in the equivalent terminal of the asynchronous transfer mode (ATM) layer at the user premise. The primary goal is to find an algorithm that efficiently combats the cell delay variation (CDV) introduced by the multiplexer.
openaire   +2 more sources