Results 71 to 80 of about 31,372 (281)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
POL-MUX System for Noncoherent Optical Networks
Applied Sciences, 2021 This paper is focused on applying a polarization multiplex to passive optical networks to double their transmission bandwidth without significant changes in the distribution network.
Radim Sifta +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Subgraph Matching on Multiplex Networks
IEEE Transactions on Network Science and Engineering, 2021 An active area of research in computational science is the design of algorithms for solving the subgraph matching problem to find copies of a given template graph in a larger world graph. Prior works have largely addressed single-channel networks using a variety of approaches.
Jacob D. Moorman +4 more
openaire +3 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Scalable Multiplex Network Embedding [PDF]
Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence, 2018 Network embedding has been proven to be helpful for many real-world problems. In this paper, we present a scalable multiplex network embedding model to represent information of multi-type relations into a unified embedding space. To combine information of different types of relations while maintaining their distinctive properties, for each node, we ...
Hongming Zhang 0009 +3 more
openaire +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Effect of shortest path multiplicity on congestion of multiplex networks
New Journal of Physics, 2019 Shortest paths are representative of discrete geodesic distances in graphs, and many descriptors of networks depend on their counting. In multiplex networks, this counting is radically important to quantify the switch between layers and it has crucial ...
Albert Solé-Ribalta +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Mathematical formulation of multilayer networks [PDF]
, 2014 A network representation is useful for describing the structure of a large variety of complex systems. However, most real and engineered systems have multiple subsystems and layers of connectivity, and the data produced by such systems are very rich ...
Gómez, S. +7 more
core +1 more source