Results 171 to 180 of about 144,579 (267)

Integrated multiplex PCR and metatranscriptomics reveal upper-lower airway microbial landscapes in pediatric respiratory infections. [PDF]

Virol Sin
Wei P, Zhang L, Hu Q, Zhu A, Zhuang Z, Zhang Z, Zhang S, Chen J, Xiong X, Qu B, Zhang Y, Chen L, Xu Z, Chen Z, Zhong Q, Xing X, Li X, Gao J, He Y, Xie G, Shang J, Guo X, Jiang J, Shi Y, Zhao J, Wang Y, Zhao J, Jin Y.   +27 more
europepmc   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

Multiplex PCR for differentiating Ornithodoros tick vectors in South Africa: Proof of concept. [PDF]

Onderstepoort J Vet Res
West S, Van Emmenes J, Boshoff C.
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Multiplex PCR assay for the rapid detection of <i>Klebsiella pneumoniae</i> pathotypes. [PDF]

J Med Microbiol
Kulkarni SM, Jacob JJ, Praveen T, Aravind V, Subbulakshmi R, Preethi S, Lal B, Gunasekaran K, Manesh A, Karve SM, Sudarsana J, Bhattacharya S, Shah A, Nagaraj S, Padaki P, Jayakumar S, Mathew R, Rudresh SM, Qureshi S, Nivedhana S, Joe G, Rajni E, Walia K, Veeraraghavan B.   +23 more
europepmc   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Beyond the Petri Dish: The Performance of a Multiplex PCR-Based Pneumonia Panel in Hospitalized Patients With Lower Respiratory Tract Infection. [PDF]

Cureus
Naharia P, Sharma A, Bhatt P, Ravi AK, Joshi A, Karade S.   +5 more
europepmc   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Phage-based diagnostic assay for melioidosis using multiplex PCR targeting <i>Burkholderia</i> phage terminase genes. [PDF]

iScience
Withatanung P, Vanaporn M, Chantratita N, Chareonsudjai S, Muangsombut V, Janesomboon S, Asawalertsaeng T, Clokie MRJ, Galyov EE, Korbsrisate S.   +9 more
europepmc   +1 more source