Results 171 to 180 of about 957,735 (260)

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

A novel one-step multiplex PCR method (OS-MPCR) for efficient NGS library preparation in cancer. [PDF]

PLoS One
Feng H, Hu X, Zhang L, Zhang Q, Wang S, Lv B, Zhang Y, Shi D, Zhou P.   +8 more
europepmc   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Evaluation of clinical usefulness of a commercial multiplex PCR for diagnosing mycobacterial infections: a multicenter study. [PDF]

Microbiol Spectr
Cano-Fernandez M, Barrado L, Bermudez-Marvalc H, Cabrera-Pineda M, Diaz-De-La-Torre I, Domingo D, Hernandez S, Garcia-Martinez J, Lopez-Roa P, Loras-Gallego C, Muñoz-Egea M-C, Ruiz-Serrano M-J, Simon M, Tato M, Toro C, Valverde-Canovas JF, Viñuela-Gonzalez L, Esteban J, Salar-Vidal L.   +18 more
europepmc   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Correction: An experimental multiplex PCR/RT-PCR for detection of the main viruses associated with equine neurological disease. [PDF]

Braz J Microbiol
Scherer SO, Silva Júnior JVJ, Pedroso NH, Dionisio IF, Weiblen R, Flores EF.   +5 more
europepmc   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

A Multiplex PCR-Based Assay for Authentication of Six Commercially Important Cephalopod Species. [PDF]

Foods
Kim KR, Kim HJ, Park SJ, Bang IC.
europepmc   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Multiplex PCR to Differentiate Monkeypox Virus Clades. [PDF]

Emerg Infect Dis
Williams CT, Romero-Ramirez A, Semiu AA, Ifabumuyi SO, Greenland-Bews C, Gould S, Wooding D, Allen C, Somasundaran A, Mkpuma NN, Gado D, Adole JA, Amoo AE, Adeyemi AA, de Jarcy LB, Goffinet C, Dunning J, Semple MG, Bahizire E, Akinpelu A, Fletcher TE, Fletcher TE, Cubas-Atienzar AI, Leggio C, Adedeji A, Omoare AA, Edwards T, International Severe Acute Respiratory and Emerging Infection Consortium Investigators.   +27 more
europepmc   +1 more source